ArticleProbiotics and antimicrobial proteins2025
Silver Nanoparticles Prepared Using Magnolia officinalis Are an Effective Antimicrobial Agent on Candida albicans, Escherichia coli, and Staphylococcus aureus.
Article in Probiotics and antimicrobial proteins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Silver nanoparticles (AgNPs) prepared by plants are simple, eco-friendly, and economical. In this study, Magnolia officinalis (MO) extract was applied to synthesize MO@AgNPs. Ultraviolet-visible (UV-vis) spectrum analysis indicated a peak at 440 nm. Most of the particles were spherical with sizes from 1 to approximately 60 nm based on transmission electron microscopy (TEM). X-ray diffraction (XRD) patterns showed a face-centered cubic crystal structure. The zeta value of MO@AgNPs was - 36.5 ± 0.6 mV, which was stable at 25 °C and 4 °C. Growth kinetic studies and the Kirby-Bauer diffusion method showed significant inhibitory activity on Candida albicans (ATCC 10231), Escherichia coli (ATCC BAA-2340), and Staphylococcus aureus (ATCC 25923); the minimum inhibitory concentrations (MIC) were 3, 9, and 9 μg/mL, and corresponding minimum bactericidal concentrations (MBC) were 5, 11, and 9 μg/mL, respectively. MO@AgNPs exhibited better antifungal activity compared to AgNPs prepared using sodium citrate. Further research revealed that MO@AgNPs increased the permeability of bacterial cell membranes. Moreover, the effect of MO@AgNPs on Candida albicans was significantly enhanced by blocking autophagy. The reactive oxygen species (ROS) induced by MO@AgNPs in Candida albicans was limited and may be related to its good antioxidant activity. Finally, MO@AgNPs have no significant cytotoxicity to the human liver LO2 cell line under 20 μg/mL.
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