Evidence map›Paper›PMID 37843681›Full record

ArticleSleep & breathing = Schlaf & Atmung2024

Oxidative stress and optical coherence tomography angiography evaluation of choriocapillaris and retinal vessel density in children with obstructive sleep apnea.

Solmaz Abdolrahimzadeh, Melania Evangelisti, Irene Gattazzo, Marta Arpinelli, Giovanni Di Nardo, Di Staso Federico, Maurizio Simmaco, Gerardo Salerno, Pasquale Parisi, Gianluca Scuderi and 1 more

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Article in Sleep & breathing = Schlaf & Atmung, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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2 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Solmaz AbdolrahimzadehOphthalmology Unit, Neurosciences, Mental Health, and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, University of Rome Sapienza, Rome, Italy.
Melania EvangelistiSt. Andrea University Hospital, Via di Grottarossa 1035/1039, 00189, Rome, Rome, Italy.
Irene GattazzoOphthalmology Unit, Neurosciences, Mental Health, and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, University of Rome Sapienza, Rome, Italy.
Marta ArpinelliPaediatrics Unit, Neurosciences, Mental Health, and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, University of Rome Sapienza, Rome, Italy.
Giovanni Di NardoSt. Andrea University Hospital, Via di Grottarossa 1035/1039, 00189, Rome, Rome, Italy.
Di Staso FedericoOphthalmology Unit, Neurosciences, Mental Health, and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, University of Rome Sapienza, Rome, Italy.
Maurizio SimmacoSt. Andrea University Hospital, Via di Grottarossa 1035/1039, 00189, Rome, Rome, Italy.
Gerardo SalernoSt. Andrea University Hospital, Via di Grottarossa 1035/1039, 00189, Rome, Rome, Italy.
Pasquale ParisiSt. Andrea University Hospital, Via di Grottarossa 1035/1039, 00189, Rome, Rome, Italy.
Gianluca Scuderi *Ophthalmology Unit, Neurosciences, Mental Health, and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, University of Rome Sapienza, Rome, Italy.
Maria Pia Villa *St. Andrea University Hospital, Via di Grottarossa 1035/1039, 00189, Rome, Rome, Italy. mariapia.villa@fondazione.uniroma1.it.
Sapienza University of Rome · ITCTO Andrea Alesini · IT

Funding

Sapienza Università di Roma Prot n 156SA_2021 RIF CE 6266_2021
6 · The paper itself

Abstract

objectivesTo investigate the vascular networks of the retina and choroid using optical coherence tomography angiography (OCTA) to identify early biomarkers of obstructive sleep apnea (OSA) severity and to evaluate correlations with blood levels of oxidative stress. STUDY

designPatients with OSA were diagnosed based on video-polysomnography (PSG) and blood samples were collected to evaluate oxidative stress markers: total antioxidant status (TAS), biological antioxidant potential (BAP) test, Diacron reactive oxygen metabolites (d-ROMs) test. The eyes of children with OSA were evaluated and compared with eyes of healthy age-matched children. OCTA imaging was carried out to evaluate the choroidal and retinal vascular network density indices.

resultsA total of 31 children with OSA were recruited and compared with 10 healthy children. Choriocapillaris flow area decreased (p = 0.006) and superficial capillary plexus vessel density increased (p=0.01) with increasing severity of OSA. Children with OSA showed significant differences in TAS and d-ROMs test when compared to normal pediatric values (p<0.05). In calculating the correlations between PSG, oxidative stress, and OCTA variables, there was a negative correlation between choriocapillaris flow area and apnea hypopnea index (AHI) (p = 0.02, r

conclusionsThe severity of OSA was associated with the choroidal and retinal capillary vascular networks. The correlation of the choriocapillaris flow area with AHI and the d-ROMs test indicates the connection of the choroidal microvasculature with the number of obstructive apnea and hypopnea events and oxidative stress.

Indexed as

ChoroidOxidative StressRetinal VesselsSleep Apnea, ObstructiveTomography, Optical CoherenceChildFemaleFluorescein AngiographyHumansMalePolysomnographyChildrenIntermittent hypoxiaObstructive sleep apneaOptical coherence tomographyOxidative stress

Identifiers

PMID37843681
OpenAlexW4387661070

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.