Evidence map›Paper›PMID 37843437›Full record

Trial reportHuman vaccines & immunotherapeutics2023

Immunogenicity and safety of a new hexavalent rotavirus vaccine in Chinese infants: A randomized, double-blind, placebo-controlled phase 2 clinical trial.

Zhi-Wei Wu, Fei Jin, Qing-Liang Li, Jia-Mei Gao, Hai-Song Zhou, Kai Duan, Zhao Gao, Yan Liu, Zhi-Yong Hao, Wei Chen and 7 more

Open access · goldAbstract readRandomized Controlled TrialClinical Trial, Phase II
In one paragraph

Trial report in Human vaccines & immunotherapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 3 countries.

Zhi-Wei WuInstitute for Vaccine Clinical Research, Hebei Province Center for Disease Control and Prevention, Shijiazhuang, People's Republic of China.
Fei JinInstitute for Vaccine Clinical Research, Hebei Province Center for Disease Control and Prevention, Shijiazhuang, People's Republic of China.
Qing-Liang LiNational Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Co., Ltd, Wuhan, People's Republic of China.
Jia-Mei GaoNational Institutes for Food and Drug Control, Beijing, China.
Hai-Song ZhouZhengding County Center for Disease Control and Prevention, Zhengding, People's Republic of China.
Kai DuanNational Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Co., Ltd, Wuhan, People's Republic of China.
Zhao GaoInstitute for Vaccine Clinical Research, Hebei Province Center for Disease Control and Prevention, Shijiazhuang, People's Republic of China.
Yan LiuNational Institutes for Food and Drug Control, Beijing, China.
Zhi-Yong HaoZhengding County Center for Disease Control and Prevention, Zhengding, People's Republic of China.
Wei ChenNational Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Co., Ltd, Wuhan, People's Republic of China.
Yue-Yue LiuNational Institutes for Food and Drug Control, Beijing, China.
Ge-Lin XuNational Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Co., Ltd, Wuhan, People's Republic of China.
Biao YangNational Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Co., Ltd, Wuhan, People's Republic of China.
Ben DongNational Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Co., Ltd, Wuhan, People's Republic of China.
Jiu-Wei ZhangNational Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Co., Ltd, Wuhan, People's Republic of China.
Yu-Liang ZhaoInstitute for Vaccine Clinical Research, Hebei Province Center for Disease Control and Prevention, Shijiazhuang, People's Republic of China.
Xiao-Ming YangNational Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Co., Ltd, Wuhan, People's Republic of China.
CTS Corporation (Czechia) · CZHebei Provincial Center for Disease Control and Prevention · CNNational Institutes for Food and Drug Control · CNCenter for Disease Control · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rotavirus remains a major cause of diarrhea among 5-y-old children, and vaccination is currently the most effective and economical measure. We conducted a randomized, double-blind, placebo-controlled phase II clinical trial designed to determine the dosage, immunogenicity, and safety profile of a novel hexavalent rotavirus vaccine. In total, 480 eligible healthy infants, who were 6-12 weeks of age at the time of randomization were randomly allocated (1:1:1) to receive 10

Indexed as

RotavirusRotavirus InfectionsRotavirus VaccinesAntibodies, ViralDouble-Blind MethodEast Asian PeopleHumansImmunogenicity, VaccineImmunoglobulin AInfantVaccines, AttenuatedVaccines, CombinedAntibodies, ViralImmunoglobulin ARotavirus VaccinesVaccines, AttenuatedVaccines, CombinedimmunogenicityRotavirussafetyvaccine

Identifiers

PMID37843437
PMCPMC10580834
OpenAlexW4387660758

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.