Evidence map›Paper›PMID 37843393›Full record

ArticleThe Journal of clinical endocrinology and metabolism2024

Vertebral Body Reshaping after Fractures: An Important Index of Recovery in Glucocorticoid-Treated Children.

Jinhui Ma, Kerry Siminoski, Jacob L Jaremko, Khaldoun Koujok, Mary Ann Matzinger, Nazih Shenouda, Nagwa Wilson, Megan Cheng, Nathalie Alos, Stephanie Atkinson and 32 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Bisphosphonate treatment for secondary osteoporosis in children, youth, and young adults: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Approach to the Pediatric Patient With Glucocorticoid-Induced Osteoporosis.The Journal of clinical endocrinology and metabolism · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 12 institutions in 2 countries.

Jinhui MaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8, Canada.
Kerry SiminoskiDepartment of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB T6G 2B7, Canada.
Jacob L JaremkoDepartment of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB T6G 2B7, Canada.
Khaldoun KoujokDepartment of Radiology, Children's Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Mary Ann MatzingerDepartment of Radiology, Children's Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Nazih ShenoudaDepartment of Radiology, Children's Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Nagwa WilsonDepartment of Radiology, Children's Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Megan ChengFaculty of Health Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Nathalie AlosDépartement de pédiatrie, Université de Montréal, Montréal, QC H3T 1C5, Canada.
Stephanie AtkinsonDepartment of Pediatrics, McMaster University, Hamilton, ON L8S 4K1, Canada.ORCID 0000-0002-5680-7546
Elizabeth A CummingsDepartment of Pediatrics, Dalhousie University/IWK Health, Halifax, NS B3K 6R8, Canada.
Josephine HoDepartment of Pediatrics, University of Calgary, Calgary, AB T3B 6A8, Canada.ORCID 0000-0003-0379-4427
Celia RoddDepartment of Pediatrics and Child Health, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Anne Marie SbrocchiDepartment of Pediatrics, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3G 2M1, Canada.
Robert SteinDepartment of Pediatrics, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5W9, Canada.
Ronald BarrDepartment of Pediatrics, McMaster University, Hamilton, ON L8S 4K1, Canada.ORCID 0000-0002-5711-7440
Elizabeth CairneyDepartment of Pediatrics, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5W9, Canada.
David B DixDepartment of Pediatrics, University of British Columbia, Vancouver, BC V6H 3V4, Canada.
Conrad V FernandezDepartment of Pediatrics, Dalhousie University/IWK Health, Halifax, NS B3K 6R8, Canada.
Ronald GrantDepartment of Pediatrics, University of Toronto, Toronto, ON M5G 1X8, Canada.
Jacqueline HaltonDepartment of Pediatrics, Children's Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Sara IsraelsDepartment of Pediatrics and Child Health, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Caroline LaverdièreDépartement de pédiatrie, Université de Montréal, Montréal, QC H3T 1C5, Canada.
Victor A LewisDepartment of Pediatrics, University of Calgary, Calgary, AB T3B 6A8, Canada.
David A CabralDepartment of Pediatrics, University of British Columbia, Vancouver, BC V6H 3V4, Canada.
Adam HuberDepartment of Pediatrics, Dalhousie University/IWK Health, Halifax, NS B3K 6R8, Canada.ORCID 0000-0002-6616-1689
Kristin HoughtonDepartment of Pediatrics, University of British Columbia, Vancouver, BC V6H 3V4, Canada.
Roman JurencakDepartment of Pediatrics, Children's Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Bianca LangDepartment of Pediatrics, Dalhousie University/IWK Health, Halifax, NS B3K 6R8, Canada.
Maggie LarchéDepartment of Medicine, McMaster University, Hamilton, ON L8S 4K1, Canada.
Claire M A LeBlancDepartment of Pediatrics, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3G 2M1, Canada.
Paivi MiettunenDepartment of Pediatrics, University of Calgary, Calgary, AB T3B 6A8, Canada.
Johannes RothDepartment of Pediatrics, Children's Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Rosie ScuccimarriDepartment of Pediatrics, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3G 2M1, Canada.
Lorraine BellDepartment of Pediatrics, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3G 2M1, Canada.
Tom Blydt-HansenDepartment of Pediatrics, University of British Columbia, Vancouver, BC V6H 3V4, Canada.
Guido FillerDepartment of Pediatrics, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5W9, Canada.ORCID 0000-0003-1891-6765
Janusz FeberDepartment of Pediatrics, Children's Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Véronique PhanDépartement de pédiatrie, Université de Montréal, Montréal, QC H3T 1C5, Canada.
Kevin SmitDepartment of Pediatrics, Children's Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Frank RauchDepartment of Pediatrics, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3G 2M1, Canada.
Leanne M WardDepartment of Pediatrics, Children's Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.ORCID 0000-0003-1557-9185
University of Ottawa · CAMcGill University · CADalhousie University · CAMcMaster University · CAUniversity of British Columbia · CAUniversité de Montréal · CAUniversity of Calgary · CAWestern University · CAChildren's Hospital Research Institute of Manitoba · CAUniversity of Alberta · CAImpact · CAUniversity of Toronto · CA

Funding

Children's Hospital of Eastern Ontario Research Institute Capacity Building Awardthe University of Ottawa Research Chair Program
6 · The paper itself

Abstract

purposeIn this 6-year study we identified factors associated with spontaneous vertebral body reshaping in glucocorticoid (GC)-treated children with leukemia, rheumatic disorders, and nephrotic syndrome.

methodsSubjects were 79 children (mean age 7.4 years) who had vertebral fracture (VF) evaluation on lateral spine radiographs at least 1 year after VF detection. VF were graded using the modified Genant semiquantitative method and fracture burden for individuals was quantified using the spinal deformity index (SDI; sum of grades from T4 to L4).

resultsSixty-five children (82.3%) underwent complete vertebral body reshaping (median time from VF detection to complete reshaping 1.3 years by Cox proportional hazard modeling). Of 237 VF, the majority (83.1%) ultimately reshaped, with 87.2% reshaping in the thoracic region vs 70.7% in the lumbar region (P = .004). Cox models showed that (1) every g/m2 increase in GC exposure in the first year after VF detection was associated with a 19% decline in the probability of reshaping; (2) each unit increase in the SDI at the time of VF detection was associated with a 19% decline in the probability of reshaping [hazard ratio (HR) = 0.81; 95% confidence interval (CI) = 0.71, 0.92; P = .001]; (3) each additional VF present at the time of VF detection reduced reshaping by 25% (HR = 0.75; 95% CI = 0.62, 0.90; P = .002); and (4) each higher grade of VF severity decreased reshaping by 65% (HR = 0.35; 95% CI = 0.21, 0.57; P < .001).

conclusionAfter experiencing a VF, children with higher GC exposure, higher SDI, more severe fractures, or lumbar VF were at increased risk for persistent vertebral deformity.

Indexed as

Fractures, BoneOsteoporotic FracturesSpinal FracturesBone DensityChildGlucocorticoidsHumansVertebral BodyGlucocorticoidschildrenglucocorticoidspinal deformity indexvertebral body reshapingvertebral fracture

Identifiers

PMID37843393
PMCPMC11285050
OpenAlexW4387660962

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.