Evidence map›Paper›PMID 37843373›Full record

ArticleJournal of virology2023

A novel protein encoded by circVPS13D attenuates antiviral innate immunity by targeting MAVS in teleost fish.

Linchao Wang, Yanhong Song, Xiaolong Yan, Tianjun Xu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Linchao WangLaboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University , Shanghai, China.ORCID 0000-0002-6621-666X
Yanhong SongLaboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University , Shanghai, China.
Xiaolong YanLaboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University , Shanghai, China.
Tianjun XuLaboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University , Shanghai, China.ORCID 0000-0003-3606-8069
Shanghai Ocean University · CNQingdao National Laboratory for Marine Science and Technology · CN

Funding

MOST | National Natural Science Foundation of China (NSFC) 31822057
6 · The paper itself

Abstract

importanceThe expression of circVPS13D was upregulated with SCRV invasion, which proved that circVPS13D was involved in the regulation of the antiviral immune response. Our study revealed that the existence of circVPS13D promoted the replication of SCRV. Functionally, circVPS13D negatively regulates the antiviral responses of fish. Mechanistically, we confirmed that circVPS13D inhibited RLRs antiviral signaling pathway via the encoded protein VPS13D-170aa by targeting MAVS. Our study provided novel insights into the roles of protein-coding circRNAs and supported VPS13D-170aa as a negative regulator in the antiviral immune responses of teleost fish.

Indexed as

Fish ProteinsRNA, CircularVesicular Transport ProteinsVirus DiseasesAnimalsFish DiseasesFishesImmunity, InnateSignal TransductionFish ProteinsRNA, CircularVesicular Transport Proteinsantiviral immunitycircRNAMAVSubiquitin-proteasome

Identifiers

PMID37843373
PMCPMC10688384
OpenAlexW4387661767

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.