Evidence map›Paper›PMID 37843115›Full record

ReviewClinical infectious diseases : an official publication of the Infectious Diseases Society of America2023

Priorities and Progress in Gram-positive Bacterial Infection Research by the Antibacterial Resistance Leadership Group: A Narrative Review.

Sarah B Doernberg, Cesar A Arias, Deena R Altman, Ahmed Babiker, Helen W Boucher, C Buddy Creech, Sara E Cosgrove, Scott R Evans, Vance G Fowler, Stephanie A Fritz and 18 more

Open access · hybridAbstract readReview
In one paragraph

Review in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. A single-center retrospective study of pathogen distribution and antibiotic resistance of bloodstream infections in emergency department.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 20 institutions in 2 countries.

Sarah B DoernbergDivision of Infectious Diseases, Department of Medicine, University of California, SanFrancisco, California, USA.ORCID 0000-0003-1727-6014
Cesar A AriasDivision of Infectious Diseases, Department of Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Deena R AltmanDivision of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ahmed BabikerDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Helen W BoucherTufts University School of Medicine, Medford, Massachusetts, USA.
C Buddy CreechDivision of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Sara E CosgroveDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Scott R EvansDepartment of Biostatistics, George Washington University, Washington, District of Columbia, USA.
Vance G FowlerDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Stephanie A FritzDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA.
Toshimitsu HamasakiBiostatistics Center, George Washington University, Rockville, Maryland, USA.
Brendan J KellyDivision of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Sixto M LealDepartment of Laboratory Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Catherine LiuVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Thomas P LodiseDepartment of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York, USA.
Loren G MillerDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Jose M MunitaInstituto de Ciencias e Innovación en Medicina, Facultad de Medicina Clinica Alemana, Universidad del Desarrollo, Santiago, Chile.
Barbara E MurrayDivision of Infectious Diseases, Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Melinda M PettigrewDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA.
Felicia RuffinDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Marc H ScheetzPharmacometrics Center of Excellence, College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA.
Bo ShopsinDivision of Infectious Diseases, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Truc T TranCenter for Infectious Diseases, Houston Methodist Research Institute, Houston, Texas, USA.
Nicholas A TurnerDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Derek J WilliamsDivision of Hospital Medicine, Department of Pediatrics, Vanderbilt University School of Medicine and the Monroe Carell Jr Children's Hospital at Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Smitha ZaharoffDuke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.
Thomas L HollandDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Antibacterial Resistance Leadership Group
Duke University · USGeorge Washington University · USHouston Methodist · USAlbany College of Pharmacy and Health Sciences · USEmory University · USIcahn School of Medicine at Mount Sinai · USJohns Hopkins University · USMidwestern University · USMonroe Carell Jr. Children's Hospital · USNew York University · USThe University of Texas Health Science Center at Houston · USTufts University · USUniversidad del Desarrollo · CLUniversity of Alabama at Birmingham · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Pennsylvania · USUniversity of Washington · USVanderbilt University · USWashington University in St. Louis · US

Funding

Antibacterial Resistance Leadership Group (ARLG)UM1AI104681 · NIAID · DUKE UNIVERSITY · PI Vance G. Fowler, Henry F HENRY CHAMBERS · 2013 to 2026
$180.8M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863NIAID NIH HHS UM1 AI104681NIH HHS UM1AI104681)
6 · The paper itself

Abstract

The Antibacterial Resistance Leadership Group (ARLG) has prioritized infections caused by gram-positive bacteria as one of its core areas of emphasis. The ARLG Gram-positive Committee has focused on studies responding to 3 main identified research priorities: (1) investigation of strategies or therapies for infections predominantly caused by gram-positive bacteria, (2) evaluation of the efficacy of novel agents for infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci, and (3) optimization of dosing and duration of antimicrobial agents for gram-positive infections. Herein, we summarize ARLG accomplishments in gram-positive bacterial infection research, including studies aiming to (1) inform optimal vancomycin dosing, (2) determine the role of dalbavancin in MRSA bloodstream infection, (3) characterize enterococcal bloodstream infections, (4) demonstrate the benefits of short-course therapy for pediatric community-acquired pneumonia, (5) develop quality of life measures for use in clinical trials, and (6) advance understanding of the microbiome. Future studies will incorporate innovative methodologies with a focus on interventional clinical trials that have the potential to change clinical practice for difficult-to-treat infections, such as MRSA bloodstream infections.

Indexed as

Gram-Positive Bacterial InfectionsMethicillin-Resistant Staphylococcus aureusSepsisAnti-Bacterial AgentsChildGram-Positive BacteriaHumansLeadershipQuality of LifeAnti-Bacterial Agentsantibacterial agentsantibacterial resistancegram-positive bacterial infectionsmethicillin-resistant Staphylococcus aureusvancomycin-resistant enterococci

Identifiers

PMID37843115
PMCPMC10578051
OpenAlexW4387661021

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.