Evidence map›Paper›PMID 37842912›Full record

ArticleGut microbes2023

Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting.

Jun Sun, M Nedim Ince, Clara Abraham, Terrence Barrett, Lisa A Brenner, Yingzi Cong, Reza Dashti, Pradeep K Dudeja, David Elliott, Thomas S Griffith and 17 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 17 institutions in 1 country.

Jun SunJesse Brown Veterans Affairs Medical Center, Chicago, IL, USA.ORCID 0000-0001-7465-3133
M Nedim InceIowa City Veterans Affairs Medical Center, Lowa city, IA, USA.ORCID 0000-0003-3451-3421
Clara AbrahamMedicine, Yale University, New Haven, CT, USA.
Terrence BarrettLexington Veterans Affairs Medical Center Kentucky, Lexington, KY, USA.
Lisa A BrennerVeterans Affairs Rocky Mountain Mental Illness Research, Education, and Clinical Center, Aurora, CO, USA.
Yingzi CongMicrobiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Reza DashtiMedicine, Stony Brook University, Stony Brook, NY, USA.
Pradeep K DudejaJesse Brown Veterans Affairs Medical Center, Chicago, IL, USA.ORCID 0000-0003-2252-7703
David ElliottIowa City Veterans Affairs Medical Center, Lowa city, IA, USA.
Thomas S GriffithMinneapolis VA Medical Center, Minneapolis, MN, USA.
Peter S HeegerMedicine/Nephrology, Cedars-Sinai Medical Center in Los Angeles, Los Angeles, CA, USA.
Andrew HoisingtonVeterans Affairs Rocky Mountain Mental Illness Research, Education, and Clinical Center, Aurora, CO, USA.
Kaikobad IraniDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.
Tae Kon KimTennessee Valley Healthcare System-Nashville VA, Nashville, TN, USA.
Neeraj KapurLexington Veterans Affairs Medical Center Kentucky, Lexington, KY, USA.
Joseph LeventhalSurgery, Northwestern University, Evanston, IL, USA.
Mansour MohamadzadehMicrobiology, University of Texas Health Science Center at San Antonio, USA, TX, San Antonio.
Ece MutluJesse Brown Veterans Affairs Medical Center, Chicago, IL, USA.
Rodney NewberryWashington University in Saint Louis School of Medicine, St. Louis, MO, USA.
Jonathan U PeledAdult Bone Marrow Transplantation Service Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Israel RubinsteinJesse Brown Veterans Affairs Medical Center, Chicago, IL, USA.
Salyka Sengsayadeth
Chen Sabrina TanIowa City Veterans Affairs Medical Center, Lowa city, IA, USA.
Xiao-Di TanJesse Brown Veterans Affairs Medical Center, Chicago, IL, USA.
Eric TkaczykLexington Veterans Affairs Medical Center Kentucky, Lexington, KY, USA.
Jason WertheimSurgery, University of Arizona, Tucson, AZ, USA.
Zheng Jenny ZhangSurgery, Northwestern University, Evanston, IL, USA.
University of Illinois Chicago · USUniversity of Iowa · USMental Illness Research, Education and Clinical Centers · USNorthwestern University · USUniversity of Kentucky · USCedars-Sinai Medical Center · USJesse Brown VA Medical Center · USLexington VA Health Care System · USMemorial Sloan Kettering Cancer Center · USStony Brook University · USThe University of Texas Health Science Center at San Antonio · USThe University of Texas Medical Branch at Galveston · USUniversity of Arizona · USUniversity of Minnesota · USVanderbilt University · USWashington University in St. Louis · USYale University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
How Vitamin D Receptor Influences Intestinal BarriersR01DK114126 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Jun Sun · 2018 to 2026
$3.0M
Vitamin D Receptor Regulation of Microbiota in Intestinal EpitheliaR01DK134343 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Jun Sun · 2023 to 2026
$3.0M
Insights into a multi-hit process in the development of necrotizing enterocolitisR01DK129960 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TAN, XIAO-DI · 2022 to 2025
$2.6M
Mechanisms underlying regulation of intestinal epithelial homeostasis in sepsisR01DK123826 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TAN, XIAO-DI · 2020 to 2023
$2.4M
Vitamin D Receptor Regulation of Microbiota in Intestinal EpitheliaR01DK105118 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SUN, JUN · 2016 to 2020
$1.8M
Microbiota mechanisms and biomarkers in GVHDK08HL143189 · NHLBI · SLOAN-KETTERING INST CAN RESEARCH · PI PELED, JONATHAN · 2019 to 2023
$858k
Microbiome and intestinal barrier in ALS therapyI01BX004824 · VA · JESSE BROWN VA MEDICAL CENTER · PI SUN, JUN · 2020 to 2025
–
Milk fat globule-EGF factor 8 and hepatocyte apoptosis-induced liver wound healing responseI01BX006085 · VA · JESSE BROWN VA MEDICAL CENTER · PI Xiao-Di Tan · 2023 to 2026
–
BLRD VA I01 BX002011BLRD VA I01 BX002715BLRD VA I01 BX004824BLRD VA I01 BX005862BLRD VA I01 BX006085NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA008748NHLBI NIH HHS K08 HL143189NIDDK NIH HHS R01 DK105118NIDDK NIH HHS R01 DK114126NIDDK NIH HHS R01 DK123826NIDDK NIH HHS R01 DK129960NIDDK NIH HHS R01 DK134343NIEHS NIH HHS P30 ES027792
6 · The paper itself

Abstract

The present report summarizes the United States Department of Veterans Affairs (VA) field-based meeting titled "Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans." Our Veteran patient population experiences a high incidence of service-related chronic physical and mental health problems, such as infection, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), various forms of hematological and non-hematological malignancies, neurologic conditions, end-stage organ failure, requiring transplantation, and posttraumatic stress disorder (PTSD). We report the views of a group of scientists who focus on the current state of scientific knowledge elucidating the mechanisms underlying the aforementioned disorders, novel therapeutic targets, and development of new approaches for clinical intervention. In conclusion, we dovetailed on four research areas of interest: 1) microbiome interaction with immune cells after hematopoietic cell and/or solid organ transplantation, graft-versus-host disease (GVHD) and graft rejection, 2) intestinal inflammation and its modification in IBD and cancer, 3) microbiome-neuron-immunity interplay in mental and physical health, and 4) microbiome-micronutrient-immune interactions during homeostasis and infectious diseases. At this VA field-based meeting, we proposed to explore a multi-disciplinary, multi-institutional, collaborative strategy to initiate a roadmap, specifically focusing on host microbiome-immune interactions among those with service-related chronic diseases to potentially identify novel and translatable therapeutic targets.

Indexed as

Gastrointestinal MicrobiomeInflammatory Bowel DiseasesIrritable Bowel SyndromeMicrobiotaVeteransHumansgraft rejectiongraft-versus-host diseasegut-brain-axisgut microbiomeIBDImmunityinfectionmicronutritionmitochondriaoral microbiomeposttraumatic stress disorderviromevitamin

Identifiers

PMID37842912
PMCPMC10580853
OpenAlexW4387661003

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.