Evidence map›Paper›PMID 37842779›Full record

ArticleStroke2023

Etiology of Primary Cerebellar Intracerebral Hemorrhage Based on Topographic Localization.

Diego Incontri, Sarah Marchina, Alexander Andreev, Mitchell Wilson, Jia-Yi Wang, David Lin, Elizabeth C Heistand, Filipa Carvalho, Magdy Selim, Vasileios-Arsenios Lioutas

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Diego IncontriDepartment of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (D.I., S.M., A.A., M.W., J.-Y.W., D.L., E.C.H., F.C., M.S., V.-A.L.).ORCID 0000-0001-6764-129X
Sarah MarchinaDepartment of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (D.I., S.M., A.A., M.W., J.-Y.W., D.L., E.C.H., F.C., M.S., V.-A.L.).ORCID 0000-0002-9969-9362
Alexander AndreevDepartment of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (D.I., S.M., A.A., M.W., J.-Y.W., D.L., E.C.H., F.C., M.S., V.-A.L.).ORCID 0000-0001-6886-1112
Mitchell WilsonDepartment of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (D.I., S.M., A.A., M.W., J.-Y.W., D.L., E.C.H., F.C., M.S., V.-A.L.).
Jia-Yi WangDepartment of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (D.I., S.M., A.A., M.W., J.-Y.W., D.L., E.C.H., F.C., M.S., V.-A.L.).ORCID 0000-0002-7505-9045
David LinDepartment of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (D.I., S.M., A.A., M.W., J.-Y.W., D.L., E.C.H., F.C., M.S., V.-A.L.).
Elizabeth C HeistandDepartment of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (D.I., S.M., A.A., M.W., J.-Y.W., D.L., E.C.H., F.C., M.S., V.-A.L.).
Filipa CarvalhoDepartment of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (D.I., S.M., A.A., M.W., J.-Y.W., D.L., E.C.H., F.C., M.S., V.-A.L.).
Magdy SelimDepartment of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (D.I., S.M., A.A., M.W., J.-Y.W., D.L., E.C.H., F.C., M.S., V.-A.L.).ORCID 0000-0002-1936-3173
Vasileios-Arsenios LioutasDepartment of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (D.I., S.M., A.A., M.W., J.-Y.W., D.L., E.C.H., F.C., M.S., V.-A.L.).ORCID 0000-0002-8521-0036
Beth Israel Deaconess Medical Center · US

Funding

StATins Use in intRacerebral hemorrhage patieNts (SATURN)U01NS102289 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Magdy H Selim · 2019 to 2026
$15.7M
StAtins Use in intRacereberal hemorrhage patieNts MRI (SATURN MRI) Ancillary StudyUF1NS120871 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SELIM, MAGDY H, SHOAMANESH, ASHKAN · 2021 to 2021
$2.7M
NINDS NIH HHS U01 NS102289NINDS NIH HHS UF1 NS120871
6 · The paper itself

Abstract

backgroundCerebellar intracerebral hemorrhage (cICH) is often attributed to hypertension or cerebral amyloid angiopathy (CAA). However, deciphering the exact etiology can be challenging. A recent study reported a topographical etiologic relationship with superficial cICH secondary to CAA. We aimed to reexamine this relationship between topography and etiology in a separate cohort of patients and using the most recent Boston criteria version 2.0.

methodsWe performed a retrospective analysis of consecutive patients with primary cICH admitted to a tertiary academic center between 2000 and 2022. cICH location on brain computed tomography/magnetic resonance imaging scan(s) was divided into strictly superficial (cortex, surrounding white matter, vermis) versus deep (cerebellar nuclei, deep white matter, peduncular region) or mixed (both regions). Magnetic resonance imaging was rated for markers of cerebral small vessel disease. We assigned possible/probable versus absent CAA using Boston criteria 2.0.

resultsWe included 197 patients; 106 (53.8%) were females, median age was 74 (63-82) years. Fifty-six (28%) patients had superficial cICH and 141 (72%) deep/mixed cICH. Magnetic resonance imaging was available for 112 (57%) patients (30 [26.8%] with superficial and 82 [73.2%] with deep/mixed cICH). Patients with superficial cICH were more likely to have possible/probable CAA (48.3% versus 8.6%; odds ratio [OR], 11.43 [95% CI, 3.26-40.05];

conclusionsOur results suggest that superficial cICH is strongly associated with CAA whereas deep/mixed cICH is strongly associated with hypertensive arteriopathy.

Indexed as

Cerebral Amyloid AngiopathyHypertensionAgedCerebral HemorrhageFemaleHumansMagnetic Resonance ImagingMaleRetrospective Studiescerebral amyloid angiopathycerebral small vessel diseasehemorrhagehypertensionstroke

Identifiers

PMID37842779
PMCPMC10843011
OpenAlexW4387661153

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.