Evidence map›Paper›PMID 37842750›Full record

ArticleAmerican journal of physiology. Cell physiology2023

Del Nido cardioplegia or potassium induces Nrf2 and protects cardiomyocytes against oxidative stress.

Hongting Diao, Wujing Dai, Daniel Wurm, Yingying Lu, Lenee Shrestha, Amy He, Raymond K Wong, Qin M Chen

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Progress of Mitochondrial Function Regulation in Cardiac Regeneration.Journal of cardiovascular translational research · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hongting DiaoPerfusion Sciences Graduate Program, Department of Pharmacology College of Medicine, University of Arizona, Tucson, Arizona, United States.ORCID 0000-0002-0795-8647
Wujing DaiPerfusion Sciences Graduate Program, Department of Pharmacology College of Medicine, University of Arizona, Tucson, Arizona, United States.ORCID 0000-0002-5614-9053
Daniel WurmPerfusion Sciences Graduate Program, Department of Pharmacology College of Medicine, University of Arizona, Tucson, Arizona, United States.
Yingying LuInterdisciplinary Program in Statistics and Data Science, University of Arizona, Tucson, Arizona, United States.
Lenee ShresthaPerfusion Sciences Graduate Program, Department of Pharmacology College of Medicine, University of Arizona, Tucson, Arizona, United States.
Amy HePerfusion Sciences Graduate Program, Department of Pharmacology College of Medicine, University of Arizona, Tucson, Arizona, United States.
Raymond K WongPerfusion Sciences Graduate Program, Department of Pharmacology College of Medicine, University of Arizona, Tucson, Arizona, United States.ORCID 0000-0002-5927-8950
Qin M ChenPerfusion Sciences Graduate Program, Department of Pharmacology College of Medicine, University of Arizona, Tucson, Arizona, United States.ORCID 0000-0002-2409-7463
University of Arizona · US

Funding

Training in Environmental Toxicology of Human DiseaseT32ES007091 · NIEHS · UNIVERSITY OF ARIZONA · PI Nathan J Cherrington · 1985 to 2026
$10.7M
Nrf2 Protein Translation for Protection Against Tissue InjuryR01GM126165 · NIGMS · UNIVERSITY OF ARIZONA · PI CHEN, QIN M · 2018 to 2021
$1.7M
Mechanism and Function of Stress Induced Protein TranslationR01GM125212 · NIGMS · UNIVERSITY OF ARIZONA · PI CHEN, QIN M · 2018 to 2021
$1.4M
NIEHS NIH HHS T32 ES007091NIGMS NIH HHS R01 GM125212NIGMS NIH HHS R01 GM126165
6 · The paper itself

Abstract

Open heart surgery is often an unavoidable procedure for the treatment of coronary artery disease. The procedure-associated reperfusion injury affects postoperative cardiac performance and long-term outcomes. We addressed here whether cardioplegia essential for cardiopulmonary bypass surgery activates Nrf2, a transcription factor regulating the expression of antioxidant and detoxification genes. With commonly used cardioplegic solutions, high K

Indexed as

Coronary Artery DiseaseReperfusion InjuryAldehyde ReductaseAntioxidantsCardioplegic SolutionsHeart Arrest, InducedHumansHydrogen PeroxideKelch-Like ECH-Associated Protein 1Myocytes, CardiacNF-E2-Related Factor 2Oxidative StressPotassiumAKR1B1 protein, humanAldehyde ReductaseAntioxidantsCardioplegic SolutionsHydrogen PeroxideKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2Potassiumantioxidant and detoxification genescardiac protectionischemia and reperfusionopen heart surgerytranscription

Identifiers

PMID37842750
PMCPMC10861178
OpenAlexW4387661663

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.