Evidence map›Paper›PMID 37842657›Full record

ReviewJournal of pharmaceutical analysis2023

Metabolomics: A useful tool for ischemic stroke research.

Wentao Li, Chongyu Shao, Chang Li, Huifen Zhou, Li Yu, Jiehong Yang, Haitong Wan, Yu He

Abstract readReview
In one paragraph

Review in Journal of pharmaceutical analysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  5. Review
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  7. Review
  8. Corroborated evidence on change of metabolome after ischemic stroke due to large vessel occlusion.Metabolomics : Official journal of the Metabolomic Society · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wentao LiSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Chongyu ShaoSchool of Basic Medicine Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Chang LiSchool of Basic Medicine Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Huifen ZhouSchool of Basic Medicine Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Li YuSchool of Basic Medicine Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Jiehong YangSchool of Basic Medicine Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Haitong WanSchool of Basic Medicine Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Yu HeSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke (IS) is a multifactorial and heterogeneous disease. Despite years of studies, effective strategies for the diagnosis, management and treatment of stroke are still lacking in clinical practice. Metabolomics is a growing field in systems biology. It is starting to show promise in the identification of biomarkers and in the use of pharmacometabolomics to help patients with certain disorders choose their course of treatment. The development of metabolomics has enabled further and more biological applications. Particularly, metabolomics is increasingly being used to diagnose diseases, discover new drug targets, elucidate mechanisms, and monitor therapeutic outcomes and its potential effect on precision medicine. In this review, we reviewed some recent advances in the study of metabolomics as well as how metabolomics might be used to identify novel biomarkers and understand the mechanisms of IS. Then, the use of metabolomics approaches to investigate the molecular processes and active ingredients of Chinese herbal formulations with anti-IS capabilities is summarized. We finally summarized recent developments in single cell metabolomics for exploring the metabolic profiles of single cells. Although the field is relatively young, the development of single cell metabolomics promises to provide a powerful tool for unraveling the pathogenesis of IS.

Indexed as

BiomarkerIschemic strokeMetabolomicsPrecision medicineSingle cell metabolomics

Identifiers

PMID37842657
PMCPMC10568109

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.