Evidence map›Paper›PMID 37842638›Full record

ArticleFrontiers in molecular biosciences2023

AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of

Paul Arras, Han Byul Yoo, Lukas Pekar, Thomas Clarke, Lukas Friedrich, Christian Schröter, Jennifer Schanz, Jason Tonillo, Vanessa Siegmund, Achim Doerner and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Multiobjective VScience advances · 2026
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  12. A comprehensive overview of recent advances in generative models for antibodies.Computational and structural biotechnology journal · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Paul ArrasAntibody Discovery and Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.
Han Byul YooAntibody Discovery and Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.
Lukas PekarAntibody Discovery and Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.
Thomas ClarkeBioinformatics, EMD Serono, Billerica, MA, United States.
Lukas FriedrichComputational Chemistry and Biologics, Merck Healthcare KGaA, Darmstadt, Germany.
Christian SchröterADCs & Targeted NBE Therapeutics, Merck KGaA, Darmstadt, Germany.
Jennifer SchanzADCs & Targeted NBE Therapeutics, Merck KGaA, Darmstadt, Germany.
Jason TonilloADCs & Targeted NBE Therapeutics, Merck KGaA, Darmstadt, Germany.
Vanessa SiegmundEarly Protein Supply and Characterization, Merck Healthcare KGaA, Darmstadt, Germany.
Achim DoernerAntibody Discovery and Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.
Simon KrahAntibody Discovery and Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.
Enrico GuarneraAntibody Discovery and Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.
Stefan ZielonkaAntibody Discovery and Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.
Andreas EversAntibody Discovery and Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.
Merck (Germany) · DEMerck Serono (Italy) · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

artificial intelligence and machine learning (ML)deep learningin silico developabilitylong short-term memory (LSTM)next-generation sequencing (NGS)protein engineeringsingle domain antibodies (VHH)yeast surface display (YSD)

Identifiers

PMID37842638
PMCPMC10575757
OpenAlexW4387312216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.