Evidence map›Paper›PMID 37842516›Full record

ArticleResearch in pharmaceutical sciences

Metabolomic identification of biochemical changes induced by fluoxetine in an insulinoma cell line (MIN6).

Surachai Ngamratanapaiboon, Krittaboon Pornchokchai, Siriphattarinya Wongpitoonmanachai, Petchlada Pholkla, Napatarin Srikornvit, Jiajun Mo, Patipol Hongthawonsiri, Pracha Yambangyang, Pilaslak Akrachalanont

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In one paragraph

Article in Research in pharmaceutical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Surachai NgamratanapaiboonDivision of Pharmacology, Department of Basic Medical Sciences, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Dusit, Bangkok, 10300, Thailand.
Krittaboon PornchokchaiFaculty of Medicine Vajira Hospital, Navamindradhiraj University, Dusit, Bangkok, 10300, Thailand.
Siriphattarinya WongpitoonmanachaiFaculty of Medicine Vajira Hospital, Navamindradhiraj University, Dusit, Bangkok, 10300, Thailand.
Petchlada PholklaFaculty of Medicine Vajira Hospital, Navamindradhiraj University, Dusit, Bangkok, 10300, Thailand.
Napatarin SrikornvitFaculty of Medicine Vajira Hospital, Navamindradhiraj University, Dusit, Bangkok, 10300, Thailand.
Jiajun MoFaculty of Medicine Vajira Hospital, Navamindradhiraj University, Dusit, Bangkok, 10300, Thailand.
Patipol HongthawonsiriFaculty of Medicine Vajira Hospital, Navamindradhiraj University, Dusit, Bangkok, 10300, Thailand.
Pracha YambangyangDepartment of Biomedical Engineering, Faculty of Engineering, Mahidol University, Salaya, Nakhon Pathom, 73170, Thailand.
Pilaslak AkrachalanontDepartment of Medical Sciences, Ministry of Public Health, Nonthaburi, 1100, Thailand.
Mahidol University · THNavamindradhiraj University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: The use of fluoxetine raises the risk of pancreatic beta-cell dysfunction. However, the specific mechanism behind its mechanism of action in beta cells is unknown. This study investigated the cellular response of MIN6 cells to fluoxetine using untargeted cell-based metabolomics. Experimental approach: Metabolic profiling of MIN6 cells was performed using liquid chromatography-high resolution mass spectrometry (LC-HRMS) analysis on samples prepared under optimized conditions, followed by principal component analysis, partial least squares-discriminant analysis, and pair-wise orthogonal projections to latent structures discriminant analyses. Findings/Results: Sixty-six metabolites that had been differentially expressed between the control and fluoxetine-treated groups demonstrated that the citric acid cycle is mainly perturbed by fluoxetine treatment. Conclusion and implications: The current study provides insights into the molecular mechanisms of fluoxetine effects in MIN6 cells.

Indexed as

FluoxetineHigh-resolution mass spectrometryInsulinoma cell lineLiquid chromatographyMetabolomics

Identifiers

PMID37842516
PMCPMC10568956
OpenAlexW4385882708

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.