Evidence map›Paper›PMID 37842322›Full record

ArticleContemporary clinical trials communications2023

Eliminating Monitor Overuse (EMO) type III effectiveness-deimplementation cluster-randomized trial: Statistical analysis plan.

Rui Xiao, Christopher P Bonafide, Nathaniel J Williams, Zuleyha Cidav, Christopher P Landrigan, Jennifer Faerber, Spandana Makeneni, Courtney Benjamin Wolk, Amanda C Schondelmeyer, Patrick W Brady and 2 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Contemporary clinical trials communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05132322 (Eliminating Monitor Overuse), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 65% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05132322 naactive not recruitingnot on this map

Eliminating Monitor Overuse (EMO) Hybrid Effectiveness-Deimplementation Trial

TypeinterventionalSponsorChildren's Hospital of PhiladelphiaRan2021 to 2026Enrolled9,265ConditionsBronchiolitis Acute ViralArmsEducational Outreach, Audit & Feedback (unit level), Audit & Feedback (real time, individual-level), Clinical Pathway Integrated into Electronic Health Record
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Rui XiaoDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, Blockley Hall, 423 Guardian Drive, Philadelphia, PA, 19104-6021, USA.
Christopher P BonafideSection of Hospital Medicine and Clinical Futures, Children's Hospital of Philadelphia, 3500 Civic Center Blvd, The Hub, Philadelphia, PA, 19104, USA.
Nathaniel J WilliamsSchool of Social Work, Boise State University, 1910 W. University Drive, Boise, ID, 83725, USA.
Zuleyha CidavDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market St, Philadelphia, Pennsylvania, 19104, USA.
Christopher P LandriganDivision of General Pediatrics, Boston Children's Hospital, Enders 1, 300 Longwood Ave, Boston, MA, 02115, USA.
Jennifer FaerberData Science and Biostatistics Unit, Roberts Center for Pediatric Research, Children's Hospital of Philadelphia, 2716 South Street, Philadelphia, PA, 19146, USA.
Spandana MakeneniData Science and Biostatistics Unit, Roberts Center for Pediatric Research, Children's Hospital of Philadelphia, 2716 South Street, Philadelphia, PA, 19146, USA.
Courtney Benjamin WolkDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3553 Market Street, 3rd Floor, Philadelphia, PA, 19104, USA.
Amanda C SchondelmeyerDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Patrick W BradyDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Rinad S BeidasDepartment of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, 625 North Michigan Avenue, Chicago, IL, 60661, USA.
Enrique F SchistermanDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, Blockley Hall, 423 Guardian Drive, Philadelphia, PA, 19104-6021, USA.
Children's Hospital of Philadelphia · USCincinnati Children's Hospital Medical Center · USUniversity of Pennsylvania · USBoise State University · USBoston Children's Hospital · USNorthwestern University · US

Funding

Eliminating Monitor Overuse (EMO) Hybrid Effectiveness-Deimplementation TrialU01HL159880 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI BEIDAS, RINAD SARY, BONAFIDE, CHRISTOPHER PETER · 2021 to 2025
$5.3M
NHLBI NIH HHS U01 HL159880
6 · The paper itself

Abstract

Background: Deimplementing overused health interventions is essential to maximizing quality and value while minimizing harm, waste, and inefficiencies. Three national guidelines discourage continuous pulse oximetry (SpO Methods: The EMO Trial is a hybrid type 3 effectiveness-deimplementation trial with a longitudinal cluster-randomized design, conducted in Pediatric Research in Inpatient Settings Network hospitals. The primary outcome is deimplementation sustainment, analyzed as a longitudinal difference-in-differences comparison between study arms. This analysis will use generalized hierarchical mixed-effects models for longitudinal clustering outcomes. Secondary outcomes include the length of hospital stay and oxygen supplementation duration, modeled using linear mixed-effects regressions. Using the well-established counterfactual approach, we will also perform a mediation analysis of hospital-level mechanistic measures on the association between the deimplementation strategy and the sustainment outcome. Discussion: We anticipate that the EMO Trial will advance the science of deimplementation by providing new insights into the processes, mechanisms, and likelihood of sustained practice change using rigorously designed deimplementation strategies. This pre-specified statistical analysis plan will mitigate reporting bias and support data-driven approaches. Trial registration: ClinicalTrials.gov NCT05132322. Registered on 24 November 2021.

Indexed as

BronchiolitisCluster randomized trialDeimplementation sustainmentOverusePulse oximetry

Identifiers

PMID37842322
PMCPMC10568304
OpenAlexW4387246315

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.