Evidence map›Paper›PMID 37841853›Full record

ArticleResearch square2023

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction.

Corina Amor, Inés Fernández-Maestre, Saria Chowdhury, Yu-Jui Ho, Sandeep Nadella, Courtenay Graham, Sebastian E Carrasco, Emmanuella Nnuji-John, Judith Feucht, Clemens Hinterleitner and 9 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 24 citations in OpenAlex.

  1. [CAR T cells in non-malignant diseases].Innere Medizin (Heidelberg, Germany) · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 2 countries.

Corina AmorCold Spring Harbor Laboratory. Cold Spring Harbor, NY, USA.
Inés Fernández-MaestreHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Saria ChowdhuryCold Spring Harbor Laboratory. Cold Spring Harbor, NY, USA.
Yu-Jui HoDepartment of Cancer Biology and Genetics. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sandeep NadellaCold Spring Harbor Laboratory. Cold Spring Harbor, NY, USA.
Courtenay GrahamDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sebastian E CarrascoLaboratory of Comparative Pathology. Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center, and Rockefeller University, New York, NY, USA.
Emmanuella Nnuji-JohnCold Spring Harbor Laboratory. Cold Spring Harbor, NY, USA.
Judith FeuchtCenter for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Clemens HinterleitnerDepartment of Cancer Biology and Genetics. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Valentin J A BarthetDepartment of Cancer Biology and Genetics. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jacob A BoyerLewis Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ, USA.
Riccardo MezzadraDepartment of Cancer Biology and Genetics. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Matthew G WereskiHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
David A TuvesonCold Spring Harbor Laboratory. Cold Spring Harbor, NY, USA.
Ross L LevineHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lee W JonesDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Michel SadelainCenter for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Scott W LoweDepartment of Cancer Biology and Genetics. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Memorial Sloan Kettering Cancer Center · USCold Spring Harbor Laboratory · USPrinceton University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9M
Pancreatic Cancer Detection ConsortiumU01CA210240 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Michael A. Hollingsworth · 2017 to 2026
$12.9M
CSHL-JAX Patient-Derived Models of Pancreatic Cancer as Systems for Investigating Tumor HeterogeneityU01CA224013 · NCI · COLD SPRING HARBOR LABORATORY · PI ROBSON, PAUL, TUVESON, DAVID A · 2018 to 2022
$4.2M
Targeting aberrant enhancer landscapes in pancreatic cancerR01CA229699 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Christopher Vakoc · 2019 to 2026
$3.3M
Toward development of senolytic CAR T cellsRF1AG065396 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI LOWE, SCOTT W., SADELAIN, MICHEL WJ · 2025 to 2025
$3.3M
Nrf2 Regulation of Ductal Pancreatic Cancer Etiology and Treatment ResponseR01CA188134 · NCI · COLD SPRING HARBOR LABORATORY · PI TUVESON, DAVID A · 2017 to 2021
$3.0M
Toward development of senolytic CAR T cellsR01AG065396 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI LOWE, SCOTT W., SADELAIN, MICHEL WJ · 2020 to 2024
$2.7M
Deconstructing aging with senolytic CAR T cellsDP5OD033055 · OD · COLD SPRING HARBOR LABORATORY · PI AMOR VEGAS, CORINA · 2022 to 2025
$2.4M
(PQA-4) Organoid Omics To Detect And Defeat Ductal Pancreatic CancerR01CA190092 · NCI · COLD SPRING HARBOR LABORATORY · PI TUVESON, DAVID A · 2014 to 2017
$2.2M
Harnessing CAR T cells to deconstruct the interconnectivity among hallmarks of agingR01AG082800 · NIA · COLD SPRING HARBOR LABORATORY · PI Corina Amor Vegas · 2023 to 2026
$2.1M
Graphical Processing Units and a Large-Memory Compute Node for Applications in Genomics, Neuroscience, and Structural BiologyS10OD028632 · OD · COLD SPRING HARBOR LABORATORY · PI SIEPEL, ADAM CHARLES · 2020 to 2020
$437k
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA045508NCI NIH HHS R01 CA188134NCI NIH HHS R01 CA190092NCI NIH HHS R01 CA229699NCI NIH HHS U01 CA210240NCI NIH HHS U01 CA224013NIA NIH HHS R01 AG065396NIA NIH HHS R01 AG082800NIA NIH HHS RF1 AG065396NIH HHS DP5 OD033055NIH HHS S10 OD028632
6 · The paper itself

Abstract

Senescent cells accumulate in organisms over time because of tissue damage and impaired immune surveillance and contribute to age-related tissue decline

Identifiers

PMID37841853
PMCPMC10571605
OpenAlexW4387058620

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.