ArticleiScience2023
Microsatellites used in forensics are in regions enriched for trait-associated variants.
Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- National and state-level datasets of United States forensic DNA databases 2001-2025.Scientific data · 2026Article
- Legitimacy of investigative forensic genetic genealogy under Art. 8 ECHR.Forensic science international. Synergy · 2025Article
- Implementation of NGS and SNP microarrays in routine forensic practice: opportunities and barriers.BMC genomics · 2025Review
- Benchmarking for genotyping and imputation using degraded DNA for forensic applications across diverse populations.Forensic science international. Genetics · 2025Article
- Law enforcement use of genetic genealogy databases in criminal investigations: Nomenclature, definition and scope.Forensic science international. Synergy · 2024Article
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7 authors.
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Abstract
The 20 short tandem repeat (STR) loci of the combined DNA index system (CODIS) are the basis of the vast majority of forensic genetics in the United States. One argument for permissive rules about the collection of CODIS genotypes is that the CODIS loci are thought to contain little information about ancestry or traits. However, in the past 20 years, a growing field has identified hundreds of thousands of genotype-trait associations. Here, we conduct a survey of the landscape of such associations surrounding the CODIS loci as compared with non-CODIS STRs. Although this study cannot establish or quantify associations between CODIS genotypes and phenotypes, we find that the regions around the CODIS loci are enriched for both known pathogenic variants (> 90th percentile) and for trait-associated SNPs identified in genome-wide association studies (GWAS) (≥ 95th percentile in 10kb and 100kb flanking regions), compared with other random sets of autosomal tetranucleotide-repeat STRs.
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