Evidence map›Paper›PMID 37841295›Full record

ArticleJournal of the Intensive Care Society2023

Is high sensitivity troponin, taken regardless of a clinical indication, associated with 1 year mortality in critical care patients?

Jonathan Hinton, Maclyn Augustine, Lavinia Gabara, Mark Mariathas, Rick Allan, Florina Borca, Zoe Nicholas, Neil Gillett, Chun Shing Kwok, Paul Cook and 3 more

Abstract read
In one paragraph

Article in Journal of the Intensive Care Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jonathan HintonCoronary Research Group, University Hospital Southampton NHS Foundation Trust, Southampton, UK.ORCID https://orcid.org/0000-0003-1670-5550
Maclyn AugustineCoronary Research Group, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Lavinia GabaraCoronary Research Group, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Mark MariathasCoronary Research Group, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Rick AllanDepartment of Biochemistry, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Florina BorcaNIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Zoe NicholasCoronary Research Group, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Neil GillettDepartment of Biochemistry, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Chun Shing KwokKeele Cardiovascular Research Group, Centre for Prognosis Research, Keele University, Stoke on Trent, UK.
Paul CookDepartment of Biochemistry, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Michael Pw GrocottFaculty of Medicine, University of Southampton, Southampton, UK.
Mamas MamasKeele Cardiovascular Research Group, Centre for Prognosis Research, Keele University, Stoke on Trent, UK.
Nick CurzenCoronary Research Group, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to assess whether high sensitivity troponin (hs-cTnI) is associated with 1 year mortality in critical care (CC). One year mortality data were obtained from NHS Digital for a consecutive cohort of patients admitted to general CC unit (GCCU) and neuroscience CC unit (NCCU) who had hs-cTnI tests performed throughout their CC admission, regardless of whether the test was clinically indicated. Cox proportional hazards were used to estimate the risk of 1-year mortality. A landmark analysis was undertaken to assess whether any relationship at 1 year was driven by mortality within the first 30 days. A total of 1033 consecutive patients were included. At 1 year 254 (24.6%) patients had died. The admission log(10)hs-cTnI concentration in the entire cohort (HR 1.35 (95% CI 1.05-1.75)

Indexed as

critical careHigh sensitivity troponinmyocardial infarction

Identifiers

PMID37841295
PMCPMC10572482

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.