ArticleFrontiers in psychiatry2023
Clinical characteristics and cognitive function in bipolar disorder patients with different onset symptom.
Article in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- The Mechanisms by Which RhoA Activity and Associated Synaptic Effects Are Controlled by the DISC1 Scaffolding-Like Protein.Biological psychiatry · 2026Article
- The correlation between high temperature and cognitive function: a CHARLS 2018 cross-sectional study.Archives of public health = Archives belges de sante publique · 2025Article
- Different prefrontal cortex activity patterns in bipolar and unipolar depression during verbal fluency tasks based on functional near infrared spectroscopy study.Scientific reports · 2025Article
- Effectiveness of Serious Games as Digital Therapeutics for Enhancing the Abilities of Children With Attention-Deficit/Hyperactivity Disorder (ADHD): Systematic Literature Review.JMIR serious games · 2025Review
- Factors associated with cognitive impairment for people with mental health disorders: screening from general hospitals and an emergency care unit in Brazil.BMC psychiatry · 2025Article
- Alterations of subcortical structure volume in pediatric bipolar disorder patients with manic or depressive first-episode.BMC psychiatry · 2024Article
- A Magnetic Resonance Spectroscopy Study on Polarity Subphenotypes in Bipolar Disorder.Diagnostics (Basel, Switzerland) · 2024Article
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8 authors.
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Abstract
Background: In recent years, studies on the clinical features and cognitive impairment of patients with different first-episode types of bipolar disorder have received increasing attention. The patients with bipolar disorder may present with different symptoms at first onset. The aim of this study is to assess the cognitive functions of a patient's index episode of bipolar disorder, depression or mania, on risk factors of effecting on cognitive functions. Method: One hundred sixty eight patients with bipolar disorder diagnosed for the first time were enrolled in the study. All patients were divided into two groups according to their index episode of bipolar disorder, either depression or mania. Seventy three patients of the cohort had an index episode mania and 95 patients had initial symptoms of depression. Demographic and clinical disease characteristic data of all enrolled patients were collected. Meanwhile, 75 healthy controls were included. Demographic data of controls were collected. The cognitive functions of all patients and controls were detected by continuous performance test (CPT), digital span test (DST) and Wisconsin card sorting test (WCST). The main cognitive functions data were compared among the mania group, depression group and control group. The relevant risk factors affecting cognitive function were analyzed. Results: (1) Most patients with bipolar disorder had an index episode depression (56.55% vs. 43.45%). Compared with the depression group, the mania group had later age of onset [(24.01 ± 4.254) vs. (22.25 ± 6.472), Conclusion: In our study, there were cognitive impairments in attention, memory, and executive function of patients with different onset syndromes of bipolar disorder. Compared with the mania group, the degree of cognitive impairments in bipolar patients with the depressive episode was more severe. The risk factors affecting cognitive impairments included the age of onset, education level, number of hospitalizations and severity of illness.
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