ArticleFrontiers in psychiatry2023
Obesity, inflammation, and depression in adolescents.
Article in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- A Clinical AI-Based System (MoodMon) for Affective Disorders: Algorithm Development and Validation.JMIR AI · 2026Article
- Explainable machine learning for depression risk prediction in adults with obesity: development of an online tool.BMC medical informatics and decision making · 2026Article
- How diet therapy affects obesity-associated depressive symptoms: from mechanism to therapeutics.Frontiers in neuroscience · 2026Review
- Article
- Depressive Symptoms in Obese Individuals Accompanied by Greater Basal Inflammation but Lower Monocyte Inflammatory Responses to LPS: A Quest to Uncover Immunologic Links between Depression and Obesity.Neuroimmunomodulation · 2026Article
- Investigation of region-of-interest-based functional connectivity within the default mode network among adolescents with depression complicated by obesity.BMC psychiatry · 2025Article
- Effect of Visceral Adipose Tissue on Major Depressive Disorder: A Mendelian Randomisation Research.Actas espanolas de psiquiatria · 2025Article
- Artificial Intelligence-Based Methods and Omics for Mental Illness Diagnosis: A Review.Bioengineering (Basel, Switzerland) · 2025Review
- The Role of Adipokines and Gene Polymorphisms in the Development of Obesity- Induced Depression.Current obesity reports · 2025Review
- The relationship between menstrual issues and depressive and anxiety symptoms in Chinese adolescent female inpatients: a cross-sectional questionnaire-based investigation.BMC psychology · 2025Article
- Mediating effect of pro-inflammatory cytokines in the association between depression, anxiety, and cardiometabolic disorders in an ethnically diverse middle-aged and older population.medRxiv : the preprint server for health sciences · 2025Article
- Association between adolescent life events and depressive symptoms: data from the Shanghai area.Frontiers in psychiatry · 2025Article
- Exploring the Interplay of Genetics and Nutrition in the Rising Epidemic of Obesity and Metabolic Diseases.Nutrients · 2024Review
- Overview of Pediatric Obesity as a Disease.Pediatric clinics of North America · 2024Review
- Factors Associated with the Development of Depression and the Influence of Obesity on Depressive Disorders: A Narrative Review.Biomedicines · 2024Review
- A New Pandemic of the XXIst Century: The Growing Crisis of Adolescent Depression in the Digital Age.Medical science monitor : international medical journal of experimental and clinical research · 2024Review
- Influence of Metabolic Dysregulation in the Management of Depressive Disorder-Narrative Review.Nutrients · 2024Review
- Milk Fat Globule Membranes for Mental Health across the Human Lifespan.Foods (Basel, Switzerland) · 2024Review
- Dietary habits, depression and obesity: an intricate relationship to explore in pediatric preventive strategies.Frontiers in pediatrics · 2024Review
- Application of "Internet +" continuous emotion management training in patients with depression.Frontiers in psychiatry · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Background: The prevalence of depression and obesity among adolescents has markedly increased over the last few decades. A bidirectional relationship has been proposed between depression and obesity in adolescence, but it remains poorly understood. Inflammation is a phenomenon that has been implicated in both disorders. Thus, a cross-sectional study was designed to investigate inflammation as a factor in the association between obesity and depression. The goal of this study is to better understand the interplay between these two disorders. Methods: The study sample consisted of female and male, black and white adolescents aged 15-18 years. Participants were diagnosed with major depressive disorder (MDD) according to the Diagnostic and Statistical Manual of Mental Disorders-5. Depression severity was determined using the Quick Inventory of Depressive Symptomatology (QIDS). Participants completed the Childhood Trust Events Survey (CTES) and received an Early Life Stress (ELS) score based on the survey results. Those with a score of ≥4 were placed in the ELS group and those with a score ≤ 3 were placed in the non-ELS group. Anthropometric measures and a Dual Energy X-ray Absorptiometry (DEXA) scan were performed for body composition. Blood samples were collected to measure inflammatory factors. Results: Adolescents with MDD ( Conclusion: Adolescents with MDD had increased levels of inflammatory factors and many measures of adiposity. Thus, the treatment of adolescent depression should include a focus on managing body composition and reducing chronic inflammation to potentially improve treatment outcomes.
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