Evidence map›Paper›PMID 37840773›Full record

ArticleExposure and health2023

Bacterial Modification of the Association Between Arsenic and Autism-Related Social Behavior Scores.

Hannah E Laue, Yuka Moroishi, Brian P Jackson, Thomas J Palys, Emily R Baker, Susan A Korrick, Juliette C Madan, Margaret R Karagas

Abstract read
In one paragraph

Article in Exposure and health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hannah E LaueDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.ORCID 0000-0002-2578-103X
Yuka MoroishiDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.ORCID 0000-0003-4046-9340
Brian P JacksonDepartment of Earth Sciences, Dartmouth College, Hanover, NH, USA.ORCID 0000-0003-2311-2972
Thomas J PalysDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Emily R BakerDepartment of Obstetrics and Gynecology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Susan A KorrickDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Juliette C MadanDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.ORCID 0000-0003-0542-1368
Margaret R KaragasDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.ORCID 0000-0002-6398-7362

Funding

VARIATION IN BIOACCUMULATION AND BIOMAGNIFICATION OF METALS IN NORTHERN US LAKESP42ES007373 · NIEHS · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA · 1995 to 2019
$52.0M
A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort StudyUH3OD023275 · OD · DARTMOUTH COLLEGE · PI MARGARET Rita KARAGAS, Juliette Madan · 2018 to 2026
$44.3M
Relation Between In-utero Vitamin D and Immune Function in Early Childhood P20GM104416 · NIGMS · DARTMOUTH COLLEGE · PI SALAS DIAZ, LUCAS A · 2013 to 2022
$23.7M
A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort StudyUG3OD023275 · OD · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA, MADAN, JULIETTE · 2016 to 2024
$17.9M
Project 3: Placental Biomarkers of Exposure and Outcome (Marsit)P01ES022832 · NIEHS · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA · 2013 to 2018
$4.7M
Project 4: Determining How Arsenic Modulates Hedgehog Signaling During DevelopmenP20ES018175 · NIEHS · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA · 2010 to 2012
$892k
NIEHS NIH HHS P01 ES022832NIEHS NIH HHS P20 ES018175NIEHS NIH HHS P42 ES007373NIGMS NIH HHS P20 GM104416NIH HHS UG3 OD023275NIH HHS UH3 OD023275
6 · The paper itself

Abstract

Arsenic is related to neurodevelopmental outcomes and is associated with the composition of the gut microbiome. Data on the modifying role of the microbiome are limited. We probed suggestive relationships between arsenic and social behaviors to quantify the modifying role of the infant gut microbiome. We followed children for whom arsenic concentrations were quantified in 6-week-old toenail clippings. Scores on the Social Responsiveness Scale (SRS-2), which measures autism-related social behaviors, were provided by caregivers when the child was approximately 3 years of age. Metagenomic sequencing was performed on infant stools collected at 6 weeks and 1 year of age. To evaluate modification by the top ten most abundant species and functional pathways, we modeled SRS-2 total

Indexed as

ArsenicAutismBranched chain amino acidsInfant gut microbiomeMetagenomic sequencingSocial Responsiveness Scale

Identifiers

PMID37840773
PMCPMC10569445

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.