Evidence map›Paper›PMID 37840687›Full record

ArticleResearch and practice in thrombosis and haemostasis2023

COVID-19-associated venous thromboembolism: risk of recurrence and major bleeding.

Pablo Demelo-Rodriguez, Rubén Alonso-Beato, Luis Jara-Palomares, Francisco Galeano-Valle, Alessandra Bura-Riviere, Adriana Visonà, Iria Francisco, Gemma Vidal, Antonio López-Ruiz, Manuel Monreal and 1 more

Open access · goldAbstract read
In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 3 countries.

Pablo Demelo-RodriguezInternal Medicine Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Rubén Alonso-BeatoInternal Medicine Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Luis Jara-PalomaresRespiratory Department, Virgen del Rocío Hospital and Instituto de Biomedicina, Sevilla, CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.
Francisco Galeano-ValleInternal Medicine Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Alessandra Bura-RiviereDepartment of Vascular Medicine, Hôpital de Rangueil, Toulouse, France.
Adriana VisonàDepartment of Vascular Medicine, Ospedale Castelfranco Veneto, Castelfranco Veneto, Italy.
Iria FranciscoDepartment of Internal Medicine, Hospital Universitari de Girona Dr. Josep Trueta, Gerona, Spain.
Gemma VidalDepartment of Internal Medicine, Corporación Sanitaria Parc Taulí, Barcelona, Spain.
Antonio López-RuizDepartment of Internal Medicine, Hospital Comarcal de Axarquía, Málaga, Spain.
Manuel MonrealChair for the Study of Thromboembolic Disease, Faculty of Health Sciences, UCAM - Universidad Católica San Antonio de Murcia, Spain, CIBER Enfermedades Respiratorias (CIBERES), Madrid, Spain.
RIETE Investigators
Hospital General Universitario Gregorio Marañón · ESCorporació Sanitària Parc Taulí · ESHôpital Rangueil · FRHospital Comarcal de Inca · ESHospital Universitari de Girona Doctor Josep Trueta · ESInstituto de Salud Carlos III · ESOspedale Castelfranco Veneto · ITUniversidad Católica de Murcia · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Complications under anticoagulant treatment in patients with COVID-19-associated venous thromboembolism (VTE) have not been consistently reported. Objectives: This study aimed to compare the 90-day rates of VTE recurrences and major bleeding in patients with COVID-19-associated VTE versus those with VTE without COVID-19. Methods: We used the RIETE registry to compare the 3-month outcomes in patients with COVID-19-associated VTE versus those with VTE without COVID-19. Results: The study included 1,747 patients with COVID-19-associated VTE and 8,711 with VTE without COVID-19. Patients with COVID-19-associated VTE were more likely to be hospitalized at baseline and to present with pulmonary embolism. During the first 90 days, 123 patients (1.17%) developed VTE recurrences, and 266 (2.54%) experienced major bleeding. Patients with COVID-19-associated VTE had a similar rate of VTE recurrences (0.9% vs 1.2%) but a higher rate of major bleeding (4.6% vs 2.1%; Conclusion: Patients with COVID-19-associated VTE had a 5-fold higher rate of major bleeding than VTE recurrences during the first 90 days of anticoagulation. In VTE patients without COVID-19, both rates were similar. These findings highlight the importance of carefully monitoring and optimizing anticoagulation in these patients.

Indexed as

anticoagulantsCOVID-19hemorrhagepulmonary embolismvenous thromboembolism

Identifiers

PMID37840687
PMCPMC10569976
OpenAlexW4386892844

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.