ArticleHuman reproduction open2023
Risk factors associated with monozygotic twinning in offspring conceived by assisted reproductive technology.
Article in Human reproduction open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Fertility treatment and risk of cerebral palsy: has the association changed in Australia?Human reproduction (Oxford, England) · 2026Article
- Clinical outcomes of dichorionic diamniotic twin pregnancies following single versus double embryo transfer in human medically assisted reproduction.Human reproduction (Oxford, England) · 2026Article
- Incidence and risk factors of monozygotic twinning following ART: analysis of 154 671 live births resulting from single embryo transfer.Human reproduction (Oxford, England) · 2025Article
- The obstetrical and infant outcomes of trophectoderm biopsy on preimplantation genetic testing embryos after frozen single embryo transfer cycles.Journal of assisted reproduction and genetics · 2025Article
- Rising Demand for Fetoscopic Laser Therapy for Twin-to-Twin Transfusion Syndrome: Trends, Maternal Age Insights, and Future Challenges in Germany.Journal of clinical medicine · 2025Article
- High multiple pregnancy rates after double embryo transfers in human: a retrospective cohort study.Reproduction & fertility · 2025Article
- Polycystic ovary syndrome.Nature reviews. Disease primers · 2024Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
study questionWhat are the factors influencing the occurrence of monozygotic (MZ) twins in offspring conceived by assisted reproductive technology (ART)? SUMMARY ANSWER: Parental ages, the transfer of fresh versus frozen embryos, and the grade of blastocysts are all related to MZ twinning in ART offspring. WHAT IS KNOWN ALREADY: Offspring conceived by ART have significantly increased risk of MZ twins, which may be due to the characteristics of the infertile population. The objective of this study was to explore the incidence of monozygotic (MZ) twins after ART and to clarify the risk factors for MZ twinning. STUDY DESIGN SIZE DURATION: A total of 255 monozygotic twins were enrolled in this cohort study, and then matched with singletons at a ratio of 1:4 randomly (with 1020 in the control group). All offspring were conceived by single embryo transfer. PARTICIPANTS/MATERIALS SETTING
methodsThe collected data were divided into the following three aspects for analysis: characteristics of the infertile population, gamete or embryo manipulations, and factors related to embryo development. MAIN RESULTS AND THE ROLE OF CHANCE: The incidence of MZ twins was 1.638% (255 out of 15 567 pregnancies after single embryo transfers). Compared to singleton births, a significantly lower rate of frozen embryo transfers (FET; 78.0% vs 86.1% LIMITATIONS REASONS FOR CAUTION: First, our definition of MZ twins was based on twins' birth after single embryo transfers (SET), rather than ultrasound examination during early pregnancy. Second, the parental characteristics of the two groups were homogenous, so it was difficult to find any associations between infertility factors and the incidence of MZ twins. WIDER IMPLICATIONS OF THE
findingsThis multifaceted analysis of the risk factors for MZ twinning provides some information for clinical interventions in high-risk populations. STUDY FUNDING/COMPETING INTERESTS: This study was supported by the National Key Technology Research and Developmental Program of China (2022YFC2704404), CAMS Innovation Fund for Medical Sciences (2021-I2M-5-001), Taishan Scholars Program for Young Experts of Shandong Province (tsqn201909195), the Basic Science Center Program (31988101), and the Shandong Provincial Key Research and Development Program (2020ZLYS02). All authors have no conflicts of interest to declare. TRIAL REGISTRATION NUMBER: N/A.
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