Evidence map›Paper›PMID 37840151›Full record

ArticleActa obstetricia et gynecologica Scandinavica2024

TP53 mutation and human papilloma virus status as independent prognostic factors in a Norwegian cohort of vulva squamous cell carcinoma.

Harsh Nitin Dongre, Rammah Elnour, Stian Tornaas, Siren Fromreide, Liv Cecilie Vestrheim Thomsen, Ingrid Benedicte Moss Kolseth, Elisabeth Sivy Nginamau, Anne Christine Johannessen, Olav Karsten Vintermyr, Daniela Elena Costea and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Acta obstetricia et gynecologica Scandinavica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Vulvar Squamous Cell Carcinoma: Scientific Progress and Impacts to Pathology Practice.International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Harsh Nitin DongreCenter for Cancer Biomarkers CCBIO and Gade Laboratory of Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway.ORCID 0000-0003-4378-2869
Rammah ElnourCenter for Cancer Biomarkers CCBIO and Gade Laboratory of Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Stian TornaasCenter for Cancer Biomarkers CCBIO and Gade Laboratory of Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Siren FromreideCenter for Cancer Biomarkers CCBIO and Gade Laboratory of Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Liv Cecilie Vestrheim ThomsenCenter for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.
Ingrid Benedicte Moss KolsethDepartment of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
Elisabeth Sivy NginamauDepartment of Pathology, Laboratory Clinic, Haukeland University Hospital, Bergen, Norway.
Anne Christine JohannessenCenter for Cancer Biomarkers CCBIO and Gade Laboratory of Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Olav Karsten VintermyrCenter for Cancer Biomarkers CCBIO and Gade Laboratory of Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Daniela Elena CosteaCenter for Cancer Biomarkers CCBIO and Gade Laboratory of Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Line BjørgeCenter for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0002-0240-2770
Haukeland University Hospital · NOUniversity of Bergen · NO

Funding

Helse Vest 912260Norwegian Agency for International Cooperation and Quality Enhancement in Higher Education CPEA-LT-2016/10106the Norwegian Women's Public Health Association 40021The Research Council of Norway 223250
6 · The paper itself

Abstract

introductionVulva squamous cell carcinoma (VSCC) develops through two separate molecular pathways-one involving high-risk human papilloma virus infection (HPV-associated), and the other without HPV infection (HPV-independent) often involving TP53 mutation. HPV-associated VSCC generally has a better progression-free survival than HPV-independent VSCC. The aim of this study was to determine TP53 mutation status using immunohistochemistry, compare different methods of HPV detection and correlate both with survival in a retrospective cohort of 123 patients with VSCC. MATERIAL AND

methodsImmunohistochemistry for p53, Ki67 and p16

resultsThe results of p53 and p16

conclusionsp53 and p16

Indexed as

Carcinoma, Squamous CellPapillomavirus InfectionsVulvar NeoplasmsCyclin-Dependent Kinase Inhibitor p16DNAFemaleHuman Papillomavirus VirusesHumansPapillomaviridaePrognosisRetrospective StudiesRNA, MessengerTumor Suppressor Protein p53VulvaCyclin-Dependent Kinase Inhibitor p16DNARNA, MessengerTP53 protein, humanTumor Suppressor Protein p53human papilloma virusin situ hybridizationprognosisTP53vulva cancervulva squamous cell carcinoma

Identifiers

PMID37840151
PMCPMC10755123
OpenAlexW4387662058

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.