Evidence map›Paper›PMID 37840122›Full record

SynthesisBMC medicine2023

Association of breastfeeding with mental disorders in mother and child: a systematic review and meta-analysis.

Polina Bugaeva, Inna Arkusha, Rinat Bikaev, Igor Kamenskiy, Aleksandra Pokrovskaya, Yasmin El-Taravi, Valeria Caso, Alla Avedisova, Derek K Chu, Jon Genuneit and 12 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Antidepressants and breastfeeding behaviors: a systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Review
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  6. Observational
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  10. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 13 institutions in 7 countries.

Polina Bugaeva *Charité - Universitätsmedizin Berlin, Einstein Center for Neurosciences, Berlin, Germany.
Inna Arkusha *V. Serbsky Federal Medical Research Center for Psychiatry and Narcology of the Ministry of Health of the Russian Federation, Moscow, Russia.
Rinat Bikaev *Moscow Research and Clinical Centre for Neuropsychiatry, Moscow, Russia.
Igor KamenskiyMoscow City Clinical Hospital After V.M. Buyanov, Moscow, Russia.
Aleksandra PokrovskayaDepartment of Brain Sciences, Faculty of Medicine, Dementia Research Institute UK, Imperial College London, London, UK.
Yasmin El-TaraviEndocrinology Research Centre, Moscow, Russia.
Valeria CasoStroke Unit, Santa Maria Della Misericordia Hospital, University of Perugia, Perugia, Italy.
Alla AvedisovaV. Serbsky Federal Medical Research Center for Psychiatry and Narcology of the Ministry of Health of the Russian Federation, Moscow, Russia.
Derek K ChuDivision of Clinical Immunology & Allergy, Department of Medicine, and Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Canada.
Jon GenuneitDepartment of Pediatrics, Pediatric Epidemiology, Medical Faculty, Leipzig University, Leipzig, Germany.
Gabriel TorbahnDepartment of Pediatrics, Paracelsus Medical University, Klinikum Nürnberg, Universitätsklinik Der Paracelsus Medizinischen Privatuniversität Nürnberg, Nuremberg, Germany.
Timothy R NicholsonInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Dina BaimukhambetovaDepartment of Paediatrics and Paediatric Infectious Diseases, Institute of Child's Health, I.M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russia.
Aigun MursalovaDepartment of Paediatrics and Paediatric Infectious Diseases, Institute of Child's Health, I.M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russia.
Anastasia KolotilinaDepartment of Paediatrics and Paediatric Infectious Diseases, Institute of Child's Health, I.M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russia.
Svetlana GadetskayaDepartment of Paediatrics and Paediatric Infectious Diseases, Institute of Child's Health, I.M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russia.
Elena KondrikovaDepartment of Paediatrics and Paediatric Infectious Diseases, Institute of Child's Health, I.M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russia.
Mikhail ZinchukMoscow Research and Clinical Centre for Neuropsychiatry, Moscow, Russia.
Renat AkzhigitovMoscow Research and Clinical Centre for Neuropsychiatry, Moscow, Russia.
Robert J BoyleNational Heart and Lung Institute, Imperial College London, London, UK. r.boyle@imperial.ac.uk.
Alla GuekhtMoscow Research and Clinical Centre for Neuropsychiatry, Moscow, Russia.
Daniel MunblitNational Heart and Lung Institute, Imperial College London, London, UK. daniel.munblit08@imperial.ac.uk.ORCID http://orcid.org/0000-0001-9652-6856
Sechenov University · RUMoscow Research and Clinical Center for Neuropsychiatry · RUDeutsches Jugendinstitut · DEEinstein Center for Neurosciences Berlin · DEEndocrinology Research Center · RUImpact · CAKing's College London · GBLung Institute · USMinistry of Health of the Russian Federation · RUMoscow City Clinical Hospital after V.M. Buyanov · RUParacelsus Medical University · ATUK Dementia Research Institute · GBUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBreastfeeding has long been associated with numerous benefits for both mothers and infants. While some observational studies have explored the relationship between breastfeeding and mental health outcomes in mothers and children, a systematic review of the available evidence is lacking. The purpose of this study is to systematically evaluate the association between breastfeeding and mental health disorders in mothers and children.

methodsWe systematically searched MEDLINE and EMBASE from inception to June 2, 2023. The inclusion criteria consisted of all studies evaluating links between breastfeeding and development of mental health disorders in children and mothers. Risk of bias was assessed using the Newcastle-Ottawa Scale (NOS) while grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to assess the certainty of evidence. A random-effects meta-analysis was used if possible, to estimate the odds ratio for the association between breastfeeding and mental health outcomes. The Mantel-Haenszel method was utilised for pooling ORs across studies. Study heterogeneity was assessed using the I

resultsOur review identified twenty-one original study. Of these, 18 focused on the association between breastfeeding and child health, assessing depressive disorders, schizophrenia, anxiety disorders, eating disorders and borderline personality disorder. Three studies evaluated the associations between breastfeeding and maternal mental health disorders. Three studies looking at outcomes in children showed no significant association between breastfeeding and occurrence of schizophrenia later in life (OR 0.98; 95% CI 0.57-1.71; I

conclusionsWe found limited evidence to support a protective association between breastfeeding and the development of mental health disorders in children later in life. The data regarding the association between breastfeeding and maternal mental health beyond the postnatal period is also limited. The methodological limitations of the published literature prevent definitive conclusions, and further research is needed to better understand the relationship between breastfeeding and mental health in mothers and children.

Indexed as

Breast FeedingFeeding and Eating DisordersAnxiety DisordersChildFemaleHumansInfantMental HealthMothersAnxiety disordersBreastfeedingChild healthDepressive disordersMaternal healthMental healthSchizophreniaSystematic review

Identifiers

PMID37840122
PMCPMC10577970
OpenAlexW4387651710

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.