Evidence map›Paper›PMID 37840068›Full record

ArticleInsights into imaging2023

Preoperative prediction of clinical and pathological stages for patients with esophageal cancer using PET/CT radiomics.

Xiyao Lei, Zhuo Cao, Yibo Wu, Jie Lin, Zhenhua Zhang, Juebin Jin, Yao Ai, Ji Zhang, Dexi Du, Zhifeng Tian and 3 more

Open access · goldAbstract read
In one paragraph

Article in Insights into imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 20 citations in OpenAlex.

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  17. More than meets the eye: 2-[European journal of nuclear medicine and molecular imaging · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Xiyao Lei *Department of Radiation Oncology, Lishui Municipal Central Hospital, Lishui, 323000, China.
Zhuo Cao *Department of Respiratory, Lishui People's Hospital, Lishui, 323000, China.
Yibo Wu *Department of Radiotherapy Center, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Jie LinDepartment of Nuclear Medicine, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Zhenhua ZhangDepartment of Radiology, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Juebin JinDepartment of Radiotherapy Center, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Yao AiDepartment of Radiotherapy Center, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Ji ZhangDepartment of Radiotherapy Center, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Dexi DuDepartment of Radiation Oncology, Lishui Municipal Central Hospital, Lishui, 323000, China.
Zhifeng TianDepartment of Radiation Oncology, Lishui Municipal Central Hospital, Lishui, 323000, China.
Congying XieDepartment of Radiotherapy Center, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. wzxiecongying@163.com.
Weiwei YinDepartment of Nuclear Medicine, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. wzmedctywww@sina.cn.
Xiance JinDepartment of Radiation Oncology, Lishui Municipal Central Hospital, Lishui, 323000, China. jinxc1979@hotmail.com.ORCID http://orcid.org/0000-0002-4117-5953
Wenzhou Medical University · CNLishui Central Hospital · CNLishui City People's Hospital · CN

Funding

The key R & D project of the Department of Science and Technology of Zhejiang Province 2020C03028The Major Project of Wenzhou Science and Technology Bureau 2020ZY0013The Major Project of Wenzhou Science and Technology Bureau ZY2022016Wenzhou Municipal Science and Technology Bureau H20180003Zhejiang Engineering Research Center for Innovation and Application of Intelligent Radiotherapy Technology LTGY23H180010
6 · The paper itself

Abstract

backgroundPreoperative stratification is critical for the management of patients with esophageal cancer (EC). To investigate the feasibility and accuracy of PET-CT-based radiomics in preoperative prediction of clinical and pathological stages for patients with EC.

methodsHistologically confirmed 100 EC patients with preoperative PET-CT images were enrolled retrospectively and randomly divided into training and validation cohorts at a ratio of 7:3. The maximum relevance minimum redundancy (mRMR) was applied to select optimal radiomics features from PET, CT, and fused PET-CT images, respectively. Logistic regression (LR) was applied to classify the T stage (T

resultsSeven, 10, and 7 CT features; 7, 8, and 7 PET features; and 3, 6, and 3 fused PET/CT features were selected using mRMR for the prediction of T stage, LNM, and pstage, respectively. The area under curves (AUCs) for T stage, LNM, and pstage prediction in the validation cohorts were 0.846, 0.756, 0.665, and 0.815; 0.769, 0.760, 0.665, and 0.824; and 0.727, 0.785, 0.689, and 0.837 for models of CT_LR_Score, PET_ LR_Score, Fused_ LR_Score, and CT + PET_ LR_Score, respectively.

conclusionsAccurate prediction ability was observed with combined PET and CT radiomics in the prediction of T stage, LNM, and pstage for EC patients. CRITICAL RELEVANCE STATEMENT: PET/CT radiomics is feasible and promising to stratify stages for esophageal cancer preoperatively. KEY POINTS: • PET-CT radiomics achieved the best performance for Node and pathological stage prediction. • CT radiomics achieved the best AUC for T stage prediction. • PET-CT radiomics is feasible and promising to stratify stages for EC preoperatively.

Indexed as

Esophageal neoplasmsLymphatic metastasisNeoplasm stagingPET-CT

Identifiers

PMID37840068
PMCPMC10577114
OpenAlexW4387652367

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.