Evidence map›Paper›PMID 37839913›Full record

ReviewTrends in parasitology2023

How colonization bottlenecks, tissue niches, and transmission strategies shape protozoan infections.

Dana A May, Fatima Taha, Matthew A Child, Sarah E Ewald

Abstract readReview
In one paragraph

Review in Trends in parasitology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dana A MayDepartment of Microbiology, Immunology, and Cancer Biology at the Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Fatima TahaDepartment of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Matthew A ChildDepartment of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. Electronic address: m.child@imperial.ac.uk.
Sarah E EwaldDepartment of Microbiology, Immunology, and Cancer Biology at the Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. Electronic address: se2s@virginia.edu.

Funding

INFECTIOUS DISEASES TRAINING PROGRAMT32AI007046 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Alison K Criss, William A Petri · 1985 to 2026
$15.3M
Global Biothreats Training ProgramT32AI055432 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CRISS, ALISON K, PETRI, WILLIAM A · 2003 to 2022
$4.0M
Innate Inflammatory Control of CachexiaR35GM138381 · NIGMS · UNIVERSITY OF VIRGINIA · PI Sarah E. Ewald · 2020 to 2026
$2.9M
Proteomic interrogation of the parasite vacuole using autoSTOMPR21AI156153 · NIAID · UNIVERSITY OF VIRGINIA · PI EWALD, SARAH E. · 2021 to 2022
$444k
National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/S001239/1NIAID NIH HHS R21 AI156153NIAID NIH HHS T32 AI007046NIGMS NIH HHS R35 GM138381Wellcome TrustWellcome Trust 202553/Z/16/Z
6 · The paper itself

Abstract

Protozoan pathogens such as Plasmodium spp., Leishmania spp., Toxoplasma gondii, and Trypanosoma spp. are often associated with high-mortality, acute and chronic diseases of global health concern. For transmission and immune evasion, protozoans have evolved diverse strategies to interact with a range of host tissue environments. These interactions are linked to disease pathology, yet our understanding of the association between parasite colonization and host homeostatic disruption is limited. Recently developed techniques for cellular barcoding have the potential to uncover the biology regulating parasite transmission, dissemination, and the stability of infection. Understanding bottlenecks to infection and the in vivo tissue niches that facilitate chronic infection and spread has the potential to reveal new aspects of parasite biology.

Indexed as

ParasitesPlasmodiumProtozoan InfectionsToxoplasmaAnimalsHost-Parasite InteractionsHumanscellular barcodinghost colonizationprotozoan parasitesstochastic bottleneckstransmission niches

Identifiers

PMID37839913
PMCPMC12767541

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.