Evidence map›Paper›PMID 37839887›Full record

ArticleInternal medicine (Tokyo, Japan)2024

Insulinoma with Hyperprocalcitoninemia and Hypercalcitoninemia Showing Coexpression of Insulin and Calcitonin in Its Tumor Cells.

Tomoko Kaketaka, Ikuo Mineo, Yu Kimura, Naohiko Ito, Yukiyoshi Okauchi, Hiromi Tamura, Shiro Adachi, Hiromi Iwahashi

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tomoko KaketakaDiabetes Center, Toyonaka Municipal Hospital, Japan.
Ikuo MineoDiabetes Center, Toyonaka Municipal Hospital, Japan.
Yu KimuraDiabetes Center, Toyonaka Municipal Hospital, Japan.
Naohiko ItoDiabetes Center, Toyonaka Municipal Hospital, Japan.
Yukiyoshi OkauchiDiabetes Center, Toyonaka Municipal Hospital, Japan.
Hiromi TamuraDepartment of Pathology, Toyonaka Municipal Hospital, Japan.
Shiro AdachiDepartment of Pathology, Toyonaka Municipal Hospital, Japan.
Hiromi IwahashiDiabetes Center, Toyonaka Municipal Hospital, Japan.
Toyonaka Municipal Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroendocrine neoplasms can produce multiple hormones that are released into the bloodstream, causing symptoms that vary depending on the type and quantity of hormones involved. We herein report a 63-year-old asymptomatic patient with pancreatic insulinoma who showed marked elevations in circulating calcitonin and procalcitonin levels that returned to normal following surgery. Immunohistochemical analyses confirmed the co-staining of calcitonin and insulin immunoreactivity in the tumor cells, suggesting a calcitonin-producing insulinoma. This insulinoma released calcitonin and a considerable amount of its precursor peptide, procalcitonin, resulting in both hyperprocalcitoninemia and hypercalcitoninemia.

Indexed as

CalcitoninInsulinInsulinomaPancreatic NeoplasmsProcalcitoninFemaleHumansMaleMiddle AgedCalcitoninInsulinProcalcitonincalcitonininsulinomaNENprocalcitoninproinsulin

Identifiers

PMID37839887
PMCPMC11157324
OpenAlexW4387566918

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.