Evidence map›Paper›PMID 37839879›Full record

ArticleInternal medicine (Tokyo, Japan)2023

New-onset Immune-mediated Necrotizing Myopathy and Trigeminal Neuropathy after SARS-CoV-2 mRNA Vaccination in a Patient with Rheumatoid Arthritis and Sjögren's Syndrome.

Takuma Tsuzuki Wada, Kazuhiro Yokota, Fumito Inayoshi, Sakon Sakai, Nobuhito Okumura, Mayumi Matsuda, Iichiro Osawa, Yasuto Araki, Yu Funakubo Asanuma, Yuji Akiyama and 1 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Takuma Tsuzuki WadaDepartment of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan.
Kazuhiro YokotaDepartment of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan.
Fumito InayoshiDepartment of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan.
Sakon SakaiDepartment of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan.
Nobuhito OkumuraDepartment of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan.
Mayumi MatsudaDepartment of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan.
Iichiro OsawaDepartment of Radiology, Saitama Medical University Hospital, Japan.
Yasuto ArakiDepartment of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan.
Yu Funakubo AsanumaDepartment of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan.
Yuji AkiyamaDepartment of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan.
Toshihide MimuraDepartment of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan.
Saitama Medical University · JPSaitama Medical University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present the case of a 42-year-old woman with rheumatoid arthritis and Sjögren's syndrome treated with adalimumab who developed immune-mediated necrotizing myopathy (IMNM) and trigeminal neuropathy after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination. Trigeminal neuralgia and elevated serum creatine kinase levels emerged 12 days post-vaccination, followed by myalgia in the femoral muscles. IMNM was histologically diagnosed. The pathogenesis may involve molecular mimicry between the SARS-CoV-2 spike glycoprotein and autologous tissues triggered by vaccination. This case emphasizes the association between SARS-CoV-2 vaccination, tumor necrosis factor inhibitor, IMNM, and trigeminal neuropathy, as well as the importance of monitoring immune-mediated adverse events following SARS-CoV-2 vaccination in patients with autoimmune disease.

Indexed as

Arthritis, RheumatoidAutoimmune DiseasesCOVID-19MyositisSjogren's SyndromeTrigeminal Nerve DiseasesAdultCOVID-19 VaccinesFemaleHumansRNA, MessengerSARS-CoV-2VaccinationCOVID-19 VaccinesRNA, Messengerimmune-mediated necrotizing myopathyrheumatoid arthritisSARS-CoV-2 mRNA vaccineSjögren's syndrometrigeminal neuropathy

Identifiers

PMID37839879
PMCPMC10781545
OpenAlexW4387566906

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.