Evidence map›Paper›PMID 37839656›Full record

ArticleJournal of molecular and cellular cardiology2023

Profibrotic COVID-19 subphenotype exhibits enhanced localized ER-dependent HSP47

Elizabeth R Jacobs, Gracious R Ross, Nathan Padilla, Amy Y Pan, Melodee Liegl, Andrii Puzyrenko, Shuping Lai, Qiang Dai, Nnamdi Uche, Jason C Rubenstein and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Elizabeth R JacobsDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States of America; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, United States of America; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States of America; Clement J. Zablocki VA Medical Center, Milwaukee, WI, United States of America.
Gracious R RossCardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, United States of America.
Nathan PadillaCardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, United States of America.
Amy Y PanCardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, United States of America; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States of America; Children's Research Institute, Milwaukee, WI, United States of America.
Melodee LieglCardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, United States of America; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States of America; Children's Research Institute, Milwaukee, WI, United States of America.
Andrii PuzyrenkoDepartment of Pathology, Medical College of Wisconsin, Milwaukee, WI, United States of America.
Shuping LaiDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States of America; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, United States of America.
Qiang DaiDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States of America; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, United States of America.
Nnamdi UcheCardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, United States of America; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States of America.
Jason C RubensteinDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States of America; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, United States of America.
Paula E NorthCardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, United States of America; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States of America; Children's Research Institute, Milwaukee, WI, United States of America.
El-Sayed H IbrahimCardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, United States of America; Department of Radiology, Medical College of Wisconsin, Milwaukee, WI, United States of America.
Yunguang SunCardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, United States of America; Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, United States of America.
Juan C FelixDepartment of Pathology, Medical College of Wisconsin, Milwaukee, WI, United States of America.
Hallgeir RuiCardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, United States of America; Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, United States of America.
Ivor J BenjaminDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States of America; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, United States of America; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States of America; Department of Cell Biology, Neuroanatomy and Anatomy, Medical College of Wisconsin, Milwaukee, WI, United States of America. Electronic address: ibenjamin@mcw.edu.
Medical College of Wisconsin · USChildren’s Institute · USMilwaukee VA Medical Center · US

Funding

Clinical and Translational Science AwardUL1TR001436 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI FREED, JULIE K · 2015 to 2025
$47.5M
Protein Misfolding Diseases and Oxido-Reductive PathwaysDP1OD006438 · OD · UNIVERSITY OF UTAH · PI BENJAMIN, IVOR JAMES · 2009 to 2011
$2.2M
Protein Misfolding Diseases and Oxido-Reductive PathwaysDP1HL117650 · NHLBI · UNIVERSITY OF UTAH · PI BENJAMIN, IVOR JAMES · 2012 to 2013
$1.5M
BLRD VA I01 BX003833NCATS NIH HHS UL1 TR001436NHLBI NIH HHS DP1 HL117650NIH HHS DP1 OD006438
6 · The paper itself

Abstract

We recently described a subgroup of autopsied COVID-19 subjects (∼40%), termed 'profibrotic phenotype,' who exhibited clusters of myofibroblasts (Mfbs), which were positive for the collagen-specific chaperone heat shock protein 47 (HSP47

Indexed as

COVID-19MyofibroblastsFibrosisHeartHSP47 Heat-Shock ProteinsHumansSARS-CoV-2HSP47 Heat-Shock ProteinsCOVID-19Extracellular matrix remodelingHuman autopsy heartsMyofibroblastsMyofibroblasts macrophage interactionProfibrotic phenotype

Identifiers

PMID37839656
PMCPMC11000691
OpenAlexW4387641572

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.