ArticleOphthalmology2024
Subclinical Keratoconus Detection and Characterization Using Motion-Tracking Brillouin Microscopy.
Article in Ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Early Detection of Keratoconus: Diagnostic Advances and Their Impact on Visual Outcomes: A Systematic Review.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Concordance of Corneal Tomographic Measurements Obtained via Swept-Source Optical Coherence Tomography Versus Scheimpflug Tomography.Bioengineering (Basel, Switzerland) · 2026Article
- Dual Optical Elastography Techniques Reveal the Regulation of Corneal Stiffness by Collagen XIV.Journal of biophotonics · 2026Article
- Motion-Tracking Brillouin Microscopy for Keratoconus Suspect Identification: Comparison With Multimodal Corneal Imaging.American journal of ophthalmology · 2026Article
- Global spatiotemporal biomechanics using video swin transformer: multiscale validation and clinical impact for keratoconus suspects.NPJ digital medicine · 2026Article
- Corneoscleral Morphology in Keratoconus and Its Association With Corneal Tomography and Biomechanics.Translational vision science & technology · 2026Article
- Artificial Intelligence-Derived Biomechanical Index for Early Corneal Ectasia Detection: Advancing Beyond Tomography.Ophthalmology science · 2026Article
- Correlation Analysis of Bowman's Layer Microdistortions and Corneal Biomechanics Changes Evaluated by Brillouin Microscopy After KLEx.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Advancing subclinical keratoconus detection using polarization-sensitive optical coherence tomography and artificial intelligence.Biophotonics discovery · 2026Article
- Biomechanical Characterization of Central Corneal Region Using Inflation Test and its Application to Predicting Central Corneal Response Under Intraocular Pressure.Annals of biomedical engineering · 2026Article
- Brillouin microscopy in cancer research: a review.Journal of biomedical optics · 2025Review
- Roadmap on advances in visual and physiological optics.Journal of optics (2010) · 2025Review
- Three-Dimensional Mechanical Characterization of Normal, Subclinical, and Keratoconic Corneas Using Motion Tracking Brillouin Microscopy.American journal of ophthalmology · 2025Article
- From Biophysics to Biomedical Physics.ACS bio & med chem Au · 2025Review
- Application of the Brillouin Optical Scanning System in the Regional Corneal Biomechanical Evaluation of Keratoconus and Its Correlation with Corvis ST Parameters.Bioengineering (Basel, Switzerland) · 2025Article
- Epithelial Mapping Efficacy for Subclinical Keratoconus Identification.American journal of ophthalmology · 2025Article
- Regional Biomechanical Weakening in Keratoconus Corneas Detected by In Vivo High-Frequency Ultrasound Elastography.Translational vision science & technology · 2025Article
- Comparing the Performance of Stress-Strain Index Versions 1 and 2 in Normal and Keratoconus Patients.Translational vision science & technology · 2025Article
- Strategies for Early Keratoconus Diagnosis: A Narrative Review of Evaluating Affordable and Effective Detection Techniques.Journal of clinical medicine · 2025Review
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6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo characterize focal biomechanical alterations in subclinical keratoconus (SKC) using motion-tracking (MT) Brillouin microscopy and evaluate the ability of MT Brillouin metrics to differentiate eyes with SKC from normal control eyes.
designProspective cross-sectional study.
participantsThirty eyes from 30 patients were evaluated, including 15 eyes from 15 bilaterally normal patients and 15 eyes with SKC from 15 patients.
methodsAll patients underwent Scheimpflug tomography and MT Brillouin microscopy using a custom-built device. Mean and minimum MT Brillouin values within the anterior plateau region and anterior 150 μm were generated. Scheimpflug metrics evaluated included inferior-superior (IS) value, maximum keratometry (K
main outcome measuresDiscriminative performance based on AUC, sensitivity, and specificity.
resultsNo significant differences were found between groups for age, sex, manifest refraction spherical equivalent, corrected distance visual acuity, K
conclusionsMotion-tracking Brillouin microscopy metrics effectively characterize focal corneal biomechanical alterations in eyes with SKC and clearly differentiated these eyes from control eyes, including eyes that were not differentiated accurately using Scheimpflug metrics. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.