Evidence map›Paper›PMID 37839041›Full record

ArticleJournal of neurology2024

Longitudinal predictors of health-related quality of life in isolated dystonia.

Johanna Junker, James Hall, Brian D Berman, Marie Vidailhet, Emmanuel Roze, Tobias Bäumer, Irene A Malaty, Aparna Wagle Shukla, Joseph Jankovic, Stephen G Reich and 8 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 13 institutions in 4 countries.

Johanna JunkerDepartment of Neurology, University of Luebeck, Ratzeburger Allee 160, 23538, Lübeck, SH, Germany.
James HallSouthampton Education School, University of Southampton, Southampton, UK.
Brian D BermanDepartment of Neurology, Virginia Commonwealth University, Richmond, VA, USA.
Marie VidailhetDepartement de Neurologie, AP-HP, Hopital de La Pitie-Salpetriere, Paris, France.
Emmanuel RozeDepartement de Neurologie, AP-HP, Hopital de La Pitie-Salpetriere, Paris, France.
Tobias BäumerInstitute of Systems Motor Science, University of Luebeck, Luebeck, Germany.
Irene A MalatyDepartment of Neurology, Fixel Institute for Neurologic Disorders, University of Florida, Gainesville, FL, USA.
Aparna Wagle ShuklaDepartment of Neurology, Fixel Institute for Neurologic Disorders, University of Florida, Gainesville, FL, USA.
Joseph JankovicParkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA.
Stephen G ReichDepartment of Neurology, School of Medicine, University of Maryland, Baltimore, MD, USA.
Alberto J EspayDepartment of Neurology, University of Cincinnati, Cincinnati, OH, USA.
Kevin R DuqueDepartment of Neurology, University of Cincinnati, Cincinnati, OH, USA.
Neepa PatelRUSH Parkinson's Disease and Movement Disorders Center, Department of Neurological Science, RUSH University Medical Center Chicago, Chicago, IL, USA.
Joel S PerlmutterDepartments of Neurology, Radiology and Neuroscience, Washington University in St. Louis, St. Louis, MO, USA.
H A JinnahDepartment of Neurology and Human Genetics, Emory University, Atlanta, GA, USA.
Dystonia Coalition Study Group
Valerie Brandt *School of Psychology, Centre for Innovation in Mental Health, University of Southampton, Southampton, UK.
Norbert Brüggemann *Department of Neurology, University of Luebeck, Ratzeburger Allee 160, 23538, Lübeck, SH, Germany. norbert.brueggemann@uni-luebeck.de.ORCID http://orcid.org/0000-0001-5969-6899
University of Southampton · GBUniversity of Cincinnati · USUniversity of Florida · USUniversity of Lübeck · DEBaylor College of Medicine · USCentre National de la Recherche Scientifique · FREmory University · USInstitute for Integrative and Experimental Genomics · DERush University Medical Center · USSorbonne Université · FRUniversity of Maryland, Baltimore · USVirginia Commonwealth University · USWashington University in St. Louis · US

Funding

Dystonia Coalition- Pilot ProjectU54NS116025 · NINDS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2019 to 2023
$7.1M
Dystonia CoalitionU54NS065701 · NINDS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2009 to 2014
$7.0M
Dystonia CoalitionU54TR001456 · NCATS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2015 to 2016
$2.5M
RES FACIL CONST: NEUROSCIENCE: LANGUAGE, COGNITION &BEHAVIOR, PAIN, DEPRESSIONC06RR020092 · NCRR · WASHINGTON UNIVERSITY · PI CICERO, THEODORE J · 2004 to 2004
$1.6M
NCATS NIH HHS NCATSNCATS NIH HHS U54 TR001456NCRR NIH HHS C06 RR020092NINDS NIH HHS NINDSNINDS NIH HHS U54 NS065701NINDS NIH HHS U54 NS116025
6 · The paper itself

Abstract

objectiveTo determine longitudinal predictors of health-related quality of life (HR-QoL) in an international multicenter cohort of patients with isolated dystonia.

methodsOut of 603 dystonia patients prospectively enrolled in the Natural History Dystonia Coalition study, 155 were assessed three times within 2 years for HR-QoL, symptoms of depression, generalized anxiety disorder (GAD), and social anxiety disorder (SAD), as well as dystonia severity and dystonic tremor. In addition, the impact of botulinum neurotoxin (BoNT) injections on HR-QoL was evaluated after 1 year.

resultsDepressive symptoms at baseline predicted lower HR-QoL on all subscales after 2 years (all p ≤ 0.001). Higher GAD scores at baseline predicted lower HR-QoL related to general health, pain and emotional well-being, whereas higher SAD scores predicted higher pain-related QoL after 2 years (all p ≤ 0.006). Dystonia severity at baseline predicted social functioning (p = 0.002). Neither dystonic tremor, age, or sex predicted HR-QoL at 2 years. Two latent categories were revealed across the three-time points: Category 1 with higher total HR-QoL scores (mean HR-QoL = 74.4% ± 16.1), susceptible to symptoms of depression and SAD, and Category 2 with lower total HR-QoL scores (mean HR-QoL = 45.5% ± 17.6), susceptible to symptoms of GAD. HR-QoL improved over the course of 1 year irrespective of the use of BoNT.

conclusionThe longitudinal impact of psychiatric symptoms on HR-QoL emphasizes the importance of incorporating mental health treatment, in particular also the therapy of anxiety disorders, into treatment regimens for dystonia.

Indexed as

DystoniaDystonic DisordersChild, PreschoolHumansPainQuality of LifeTremorAnxietyBoNTDepressionDystoniaQuality of life

Identifiers

PMID37839041
PMCPMC10827910
OpenAlexW4387653918

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.