Article in Islets, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors at 2 institutions in 1 country.
Sukrati KanojiaDepartment of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Rebecca K DavidsonDepartment of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Jason M ConleyCenter for Diabetes & Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.
Jerry XuDepartment of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Meredith OsmulskiCenter for Diabetes & Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.
Emily K SimsDepartment of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Hongxia RenDepartment of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Jason M SpaethDepartment of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Indiana University – Purdue University Indianapolis · USIndiana University School of Medicine
Funding
Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI JEFFREY S ELMENDORF · 2015 to 2026
$17.4M
RESEARCH TRAINING PROGRAM IN DIABETES AND OBESITYT32DK064466 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Carmella Evans-Molina, RONALD C WEK · 2003 to 2026
$5.2M
Implications of Changes in Islet Exosomal Cargo in Type 1 DiabetesR01DK133881 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI EVANS-MOLINA, CARMELLA, MIRMIRA, RAGHAVENDRA G · 2022 to 2025
$2.7M
Metabolic Function of Gpr17 in Gastrointestinal TractR01DK120772 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI REN, HONGXIA · 2020 to 2024
$2.0M
Beta cell extracellular vesicles in health and diseaseR01DK121929 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI SIMS, EMILY K · 2020 to 2024
$2.0M
The role of Pdx1-recruited Chd4:NuRD complex in controlling mature #-cell functionR01DK129287 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Jason M Spaeth · 2022 to 2026
$2.0M
Pdx1 transcriptional activity and beta-cell function are dynamically modulated bycoregulators in physiological and pathophysiological conditions associated with Type 2 diabetesK01DK115633 · NIDDK · VANDERBILT UNIVERSITY · PI SPAETH, JASON M · 2018 to 2020
$438k
Illuminating the Metabolic Function of GPR162 by Delineating Downstream Signaling Pathways and Characterizing Hypothalamic Expression PatternR03TR003350 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI REN, HONGXIA, WATTS, VAL J · 2020 to 2020
$172k
Swi/Snf chromatin remodeling activity is required for islet cell development in vivoF31DK128918 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DAVIDSON, REBECCA K · 2021 to 2021
The pancreatic β cell synthesizes, packages, and secretes insulin in response to glucose-stimulation to maintain blood glucose homeostasis. Under diabetic conditions, a subset of β cells fail and lose expression of key transcription factors (TFs) required for insulin secretion. Among these TFs is Pancreatic and duodenal homeobox 1 (PDX1), which recruits a unique subset of transcriptional coregulators to modulate its activity. Here we describe a novel interacting partner of PDX1, the Staphylococcal Nuclease and Tudor domain-containing protein (SND1), which has been shown to facilitate protein-protein interactions and transcriptional control through diverse mechanisms in a variety of tissues. PDX1:SND1 interactions were confirmed in rodent β cell lines, mouse islets, and human islets. Utilizing CRISPR-Cas9 gene editing technology, we deleted
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Dynamic regulation of pancreatic β cell function and gene expression by the SND1 coregulator · full record | OpenQuestion