ArticleCell reports2023
Entorhinal cortical delta oscillations drive memory consolidation.
Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- The effects of sleep disturbances on patients receiving methadone treatment for opioid use disorder: cortical thickness evidence.Frontiers in psychiatry · 2026Article
- An evolutionarily conserved cation channel tunes the sensitivity of gustatory neurons to ephaptic inhibition inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Exploring the relationship between features calculated from contextual embeddings and EEG band power during sentence reading in Chinese.Frontiers in neuroscience · 2025Article
- NMDA receptor antagonist induced c-Fos expression in the medial entorhinal cortex during postnatal development.Frontiers in neural circuits · 2025Article
- Spontaneous persistent activity and inactivity in vivo reveals differential cortico-entorhinal functional connectivity.Nature communications · 2024Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Long-term memories are formed by creating stable memory representations via memory consolidation, which mainly occurs during sleep following the encoding of labile memories in the hippocampus during waking. The entorhinal cortex (EC) has intricate connections with the hippocampus, but its role in memory consolidation is largely unknown. Using cell-type- and input-specific in vivo neural activity recordings, here we show that the temporoammonic pathway neurons in the EC, which directly innervate the output area of the hippocampus, exhibit potent oscillatory activities during anesthesia and sleep. Using in vivo individual and populational neuronal activity recordings, we demonstrate that a subpopulation of the temporoammonic pathway neurons, which we termed sleep cells, generate delta oscillations via hyperpolarization-activated cyclic-nucleotide-gated channels during sleep. The blockade of these oscillations significantly impaired the consolidation of hippocampus-dependent memory. Together, our findings uncover a key driver of delta oscillations and memory consolidation that are found in the EC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.