Evidence map›Paper›PMID 37838792›Full record

ArticleScientific reports2023

Cartilage oligomeric matrix protein overexpression is an independent poor prognostic indicator in patients with intrahepatic cholangiocarcinoma.

Khaa Hoo Ong, Yao-Yu Hsieh, Hong-Yue Lai, Ding-Ping Sun, Tzu-Ju Chen, Steven Kuan-Hua Huang, Yu-Feng Tian, Chia-Ling Chou, Yow-Ling Shiue, Hung-Chang Wu and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Khaa Hoo Ong *Division of Gastroenterology and General Surgery, Department of Surgery, Chi Mei Medical Center, Tainan, 710, Taiwan, ROC.
Yao-Yu Hsieh *Division of Hematology and Oncology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, 23561, Taiwan, ROC.
Hong-Yue LaiDepartment of Pharmacology, School of Medicine, College of Medicine, China Medical University, Taichung, 404, Taiwan, ROC.
Ding-Ping SunDivision of Gastroenterology and General Surgery, Department of Surgery, Chi Mei Medical Center, Tainan, 710, Taiwan, ROC.
Tzu-Ju ChenDepartment of Medical Technology, Chung Hwa University of Medical Technology, Tainan, 717, Taiwan, ROC.
Steven Kuan-Hua HuangDivision of Urology, Department of Surgery, Chi Mei Medical Center, Tainan, 710, Taiwan, ROC.
Yu-Feng TianDivision of Colon and Rectal Surgery, Department of Surgery, Chi Mei Medical Center, Tainan, 710, Taiwan, ROC.
Chia-Ling ChouDepartment of Medical Technology, Chung Hwa University of Medical Technology, Tainan, 717, Taiwan, ROC.
Yow-Ling ShiueInstitute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, 804, Taiwan, ROC.
Hung-Chang WuDivision of Hematology and Oncology, Department of Internal Medicine, Chi-Mei Medical Center, Tainan, 71004, Taiwan, ROC.
Ti-Chun ChanDepartment of Medical Research, Chi Mei Medical Center, Tainan, 710, Taiwan, ROC.
Hsin-Hwa TsaiDepartment of Laboratory Medicine, China Medical University Hospital, Taichung, 404, Taiwan, ROC.
Chien-Feng LiInstitute of Precision Medicine, National Sun Yat-Sen University, Kaohsiung, 804, Taiwan, ROC.
Po-An SuDepartment of Infectious Disease, Chi Mei Medical Center, No.901, Zhonghua Rd. Yongkang Dist, Tainan City, 71004, Taiwan, ROC. suboan0421@gmail.com.
Yu-Hsuan KuoInstitute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, 804, Taiwan, ROC. beethovan@gmail.com.
Chi Mei Medical Center · TWNational Health Research Institutes · TWChia Nan University of Pharmacy and Science · TWChina Medical University · TWChina Medical University Hospital · TWNational Sun Yat-sen University · TWTaipei Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cartilage oligomeric matrix protein (COMP) interacts with various extracellular matrix proteins in tissues. Elevated COMP levels recently linked to worse overall survival in multiple cancer types. COMP's significance in intrahepatic cholangiocarcinoma (iCCA) remains uncertain. Here we report a retrospective study to explore COMP's impact on iCCA outcomes. We collected 182 patients' iCCA tumor tissues. COMP overexpression was associated with adverse factors like R1 resection (p = 0.008), advanced T stage (p < 0.001), large duct type (p = 0.004), and poorly differentiated histology (p = 0.002). COMP overexpression correlates with poorer DFS (HR, 3.651; p = 0.001), OS (HR, 1.827; p = 0.023), LRFS (HR, 4.077; p < 0.001), and MFS (HR, 3.718; p < 0.001). High COMP expression ties to worse overall survival (p = 0.0001), DSS (p < 0.0001), LRFS (p < 0.0001), and MFS (p < 0.0001). In conclusion, COMP overexpression links to poor prognosis and pathological features in iCCA, indicating its potential as a biomarker.

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaBile Ducts, IntrahepaticCartilage Oligomeric Matrix ProteinHumansPrognosisRetrospective StudiesCartilage Oligomeric Matrix ProteinTSP5 protein, human

Identifiers

PMID37838792
PMCPMC10576746
OpenAlexW4387640247

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.