Evidence map›Paper›PMID 37838348›Full record

ArticleRegulatory toxicology and pharmacology : RTP2023

Quantitative Structure Use Relationships: Highlights from a technical summit meeting.

Rosemary T Zaleski, Andreas Ahrens, Jon A Arnot, Richard A Becker, Mark Bonnell, Sean Collins, Paul DeLeo, Peter Egeghy, Michelle Embry, Todd Gouin and 2 more

Abstract read
In one paragraph

Article in Regulatory toxicology and pharmacology : RTP, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Generic formulations: availability and applicability for exposure assessment.Journal of exposure science & environmental epidemiology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rosemary T ZaleskiLumina Consulting, L.L.C, USA. Electronic address: rzaleski10@gmail.com.
Andreas AhrensEuropean Chemicals Agency (ECHA), Finland.
Jon A ArnotARC Arnot Research and Consulting Inc, Canada.
Richard A BeckerAmerican Chemistry Council (ACC), USA.
Mark BonnellEnvironment and Climate Change Canada (ECCC), Canada.
Sean CollinsHealth Canada (HC), Canada.
Paul DeLeoAmerican Chemistry Council (ACC), USA.
Peter EgeghyEPA, Office of Research and Development (ORD), Center for Computational Toxicology and Exposure (CCTE), USA.
Michelle EmbryHealth and Environmental Sciences Institute (HESI), USA.
Todd GouinTG Environmental Research, UK.
Kristin IsaacsEPA, Office of Research and Development (ORD), Center for Computational Toxicology and Exposure (CCTE), USA.
Elke JensenDow Chemical Company, USA.

Funding

Intramural EPA EPA999999
6 · The paper itself

Abstract

The Quantitative Structure Use Relationship (QSUR) Summit, held on November 2-4, 2022, focused on advancing the development, refinement, and use of QSURs to support chemical substance prioritization and risk assessment and mitigation. QSURs utilize chemical structures to predict the function of a chemical within a formulated product or an industrial process. This presumed function can then be used to develop chemical use categories or other information necessary to refine exposure assessments. The invited expert meeting was attended by 38 scientists from Canada, Finland, France, the UK, and the USA, representing government, business, and academia, with expertise in exposure science, chemical engineering, risk assessment, formulation chemistry, and machine learning. Workshop discussions emphasized the importance of collection and sharing of data and quantification of relative chemical quantities to progress QSUR development. Participants proposed collaborative approaches to address key challenges, including mechanisms for aggregating information while still protecting proprietary product composition and other confidential business information. Discussions also led to proposals for applications beyond exposure and risk modeling, including sustainable formulation discovery. In addition, discussions continue to construct, conduct, and circulate case studies tied to various specific problem formulations in which QSURs supply or derive information on chemical functions, concentrations, and exposures.

Indexed as

Risk AssessmentCanadaFranceHumansAlternatives assessmentChemical safetyConsumer productsExposure assessmentExposure modelsFormulated productsHigh-throughput exposure assessmentNon-targeted analysisQuantitative Structure Use Relationships (QSURs)Risk assessment

Identifiers

PMID37838348
PMCPMC11295147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.