Evidence map›Paper›PMID 37838323›Full record

ArticleGastrointestinal endoscopy2024

Performance of capsule endoscopy for the detection of small intestinal neuroendocrine tumors in familial carcinoid: a prospective single-site study.

Derek Tang, Ramona Lim, Louis Korman, Joanne Forbes, Kristen Ellsbury, Sungyoung Auh, Apurva Trivedi, Clara C Chen, Marybeth Hughes, Stephen Wank

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastrointestinal endoscopy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00646022 (Natural History of Familial Carcinoid Tumor), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00646022 recruitingnot on this map

Natural History of Familial Carcinoid Tumor

TypeobservationalSponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Ran2008Enrolled1,600ConditionsCarcinoidArms[18F]-DOPA
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Derek TangDigestive Disease Branch, National Institutes of Health, Bethesda, Maryland, USA; Kaiser Permanente, Anaheim, California, USA.
Ramona LimDigestive Disease Branch, National Institutes of Health, Bethesda, Maryland, USA; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts, USA; Division of Population Sciences, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA.
Louis KormanDigestive Disease Branch, National Institutes of Health, Bethesda, Maryland, USA.
Joanne ForbesDigestive Disease Branch, National Institutes of Health, Bethesda, Maryland, USA.
Kristen EllsburyDigestive Disease Branch, National Institutes of Health, Bethesda, Maryland, USA.
Sungyoung AuhOffice of the Clinical Director, National Institutes of Health, Bethesda, Maryland, USA.
Apurva TrivediDigestive Disease Branch, National Institutes of Health, Bethesda, Maryland, USA; Hospital at Westlake Medical Center, Austin, Texas, USA.
Clara C ChenNational Institute of Diabetes and Digestive and Kidney Diseases, Nuclear Medicine Division, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Marybeth HughesSurgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA; Surgical Oncology, East Virginia Medical School, Norfolk, Virginia, USA.
Stephen WankDigestive Disease Branch, National Institutes of Health, Bethesda, Maryland, USA.
National Institutes of Health · USBrigham and Women's Hospital · US

Funding

Natural History of Familial Carcinoid TumorZIADK071010 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI WANK, STEPHEN · 2009 to 2025
$13.6M
Intramural NIH HHS ZIA DK071010
6 · The paper itself

Abstract

BACKGROUND AND

aimsSmall-bowel neuroendocrine tumors (NETs) are slow growing, clinically silent tumors whose prognosis depends on disease stage. Members of kindreds with a familial form of small intestinal NETs (SI-NETs) represent a high-risk population for whom early detection improves disease outcome. Our aim was to determine the utility of small-bowel capsule endoscopy (SB-CE) for screening high-risk asymptomatic relatives from kindreds with familial carcinoid.

methodsOne hundred seventy-four asymptomatic subjects with a family history (≥2 family members) of SI-NETs were screened under Protocol NCT00646022, Natural History of Familial Carcinoid Tumor at the National Institutes of Health. All patients were imaged with SB-CE and

resultsThirty-five of 174 asymptomatic subjects screened for SI-NETs were positive on either SB-CE or

conclusionsSB-CE is a sensitive and specific method comparable with

Indexed as

Capsule EndoscopyCarcinoid TumorNeuroendocrine TumorsDihydroxyphenylalanineHumansPositron Emission Tomography Computed TomographyProspective StudiesDihydroxyphenylalaninefluorodopa F 18

Identifiers

PMID37838323
PMCPMC13663233
OpenAlexW4387566722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.