Evidence map›Paper›PMID 37838011›Full record

ArticleThe American journal of pathology2024

DOCK2 Promotes Atherosclerosis by Mediating the Endothelial Cell Inflammatory Response.

Guoqing Qian, Oluwaseun Adeyanju, Dunpeng Cai, Torry A Tucker, Steven Idell, Shi-You Chen, Xia Guo

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Guoqing QianDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas.
Oluwaseun AdeyanjuDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas.
Dunpeng CaiDepartment of Surgery, School of Medicine, The University of Missouri, Columbia, Missouri.
Torry A TuckerDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas.
Steven IdellDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas.
Shi-You ChenDepartment of Surgery, School of Medicine, The University of Missouri, Columbia, Missouri; The Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri; Department of Physiology and Pharmacology, University of Georgia, Athens, Georgia. Electronic address: scqvd@missouri.edu.
Xia GuoDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas; Department of Physiology and Pharmacology, University of Georgia, Athens, Georgia. Electronic address: xia.guo@uthct.edu.
The University of Texas Health Science Center at Tyler · USUniversity of Georgia · USUniversity of Missouri · US

Funding

Fortilin, p53, and atherosclerosisR01HL117247 · NHLBI · UNIVERSITY OF WASHINGTON · PI CHEN, SHIYOU, FUJISE, KEN · 2013 to 2023
$4.7M
Novel mechanism of smooth muscle phenotypic modulation and vascular remodelingR01HL119053 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHEN, SHIYOU · 2014 to 2023
$3.8M
Dedicator of cytokinesis 2 in abdominal aortic aneurysmR01HL147313 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHEN, SHIYOU · 2019 to 2022
$2.1M
D0CK2 in pleural fibrosis-Diversity SupplementR01HL171576 · NHLBI · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI Guoqing Qian · 2024 to 2026
$1.2M
Dedicator of cytokinesis 2 in atherosclerosisR00HL141583 · NHLBI · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI GUO, XIA · 2020 to 2022
$747k
Dedicator of cytokinesis 2 in pleural fibrosisR56HL163554 · NHLBI · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI QIAN, GUOQING · 2022 to 2022
$363k
Novel Mechanisms Underlying the Development of AtherosclerosisI01BX006161 · VA · HARRY S. TRUMAN MEMORIAL VA HOSPITAL · PI Shiyou Chen · 2023 to 2026
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BLRD VA I01 BX006161NHLBI NIH HHS R00 HL141583NHLBI NIH HHS R01 HL117247NHLBI NIH HHS R01 HL119053NHLBI NIH HHS R01 HL147313NHLBI NIH HHS R01 HL171576NHLBI NIH HHS R56 HL163554
6 · The paper itself

Abstract

The pathology of atherosclerosis, a leading cause of mortality in patients with cardiovascular disease, involves inflammatory phenotypic changes in vascular endothelial cells. This study explored the role of the dedicator of cytokinesis (DOCK)-2 protein in atherosclerosis. Mice with deficiencies in low-density lipoprotein receptor and Dock2 (Ldlr

Indexed as

AtherosclerosisEndothelial CellsAnimalsGTPase-Activating ProteinsGuanine Nucleotide Exchange FactorsHumansInflammationIntercellular Adhesion Molecule-1MiceNF-kappa BTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1DOCK2 protein, humanDOCK2 protein, mouseGTPase-Activating ProteinsGuanine Nucleotide Exchange FactorsIntercellular Adhesion Molecule-1NF-kappa BTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1

Identifiers

PMID37838011
PMCPMC10988758
OpenAlexW4387574043

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.