Evidence map›Paper›PMID 37837555›Full record

ArticleJournal of endocrinological investigation2024

Gender-related differences in patients with carcinoid syndrome: new insights from an Italian multicenter cohort study.

R M Ruggeri, B Altieri, P Razzore, F Retta, E Sperti, G Scotto, M P Brizzi, L Zumstein, A Pia, A Lania and 32 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 20 institutions in 2 countries.

R M Ruggeri *Endocrinology Unit, Department of Human Pathology of Adulthood and Childhood DETEV, University of Messina, 98125, Messina, Italy.
B Altieri *Division of Endocrinology and Diabetes, Department of Internal Medicine, University of Würzburg, Würzburg, Germany.
P RazzoreSC Endocrinologia, Diabetologia e Malattie del Metabolismo, AO Ordine Mauriziano di Torino, Largo Turati, 62 10128, Turin, Italy.
F RettaSC Endocrinologia, Diabetologia e Malattie del Metabolismo, AO Ordine Mauriziano di Torino, Largo Turati, 62 10128, Turin, Italy.
E SpertiSCDU Oncologia, AO Ordine Mauriziano di Torino, Largo Turati, 62 10128, Turin, Italy.
G ScottoDepartment of Oncology, University Hospital San Luigi Gonzaga, University of Turin, Orbassano, Turin, Italy.
M P BrizziDepartment of Oncology, University Hospital San Luigi Gonzaga, University of Turin, Orbassano, Turin, Italy.
L ZumsteinDepartment of Oncology, University Hospital San Luigi Gonzaga, University of Turin, Orbassano, Turin, Italy.
A PiaInternal Medicine, Department of Clinical and Biological Sciences, S. Luigi Hospital, University of Turin, Turin, Italy.
A LaniaDepartment of Biomedical Sciences, Humanitas University, 20089, Pieve Emanuele, Italy.
E LavezziEndocrinology, Diabetology and Andrology Unit, IRCCS Humanitas Research Hospital, 20089, Rozzano, Italy.
G NappoDepartment of Biomedical Sciences, Humanitas University, 20089, Pieve Emanuele, Italy.
A LaffiMedical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
M AlbertelliEndocrinology Unit, Department of Internal Medicine and Medical Specialties (DIMI), University of Genova, 16132, Genoa, Italy.
M BoschettiEndocrinology Unit, Department of Internal Medicine and Medical Specialties (DIMI), University of Genova, 16132, Genoa, Italy.
I HasballaEndocrinology Unit, Department of Internal Medicine and Medical Specialties (DIMI), University of Genova, 16132, Genoa, Italy.
A VeresaniEndocrinology Unit, Department of Internal Medicine and Medical Specialties (DIMI), University of Genova, 16132, Genoa, Italy.
N PrinziMedical Oncology, Foundation IRCCS National Cancer Institute, Milan, Italy.
S PuscedduMedical Oncology, Foundation IRCCS National Cancer Institute, Milan, Italy.
S OldaniMedical Oncology, Foundation IRCCS National Cancer Institute, Milan, Italy.
F NichettiMedical Oncology, Foundation IRCCS National Cancer Institute, Milan, Italy.
R ModicaEndocrinology, Diabetology and Andrology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy.
R MinottaEndocrinology, Diabetology and Andrology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy.
A LiccardiEndocrinology, Diabetology and Andrology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy.
G CannavaleEndocrinology, Diabetology and Andrology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy.
E M GrossrubatscherEndocrine Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
M G TarsitanoDepartment of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
V ZamponiEndocrinology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, ENETS Center of Excellence, Rome, Italy. virginia.zamponi@uniroma1.it.ORCID http://orcid.org/0000-0002-2422-9673
M C ZatelliSection of Endocrinology, Geriatrics and Internal Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
I ZanataSection of Endocrinology, Geriatrics and Internal Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
R MazzilliEndocrinology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, ENETS Center of Excellence, Rome, Italy.
M AppetecchiaOncological Endocrinology Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
M V DavìDepartment of Medicine, Section of Endocrinology, University and Hospital Trust of Verona, Verona, Italy.
V GuarnottaDipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro" (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, 90127, Palermo, Italy.
E GiannettaDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
A La SalviaDivision of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, 00144, Rome, Italy.
G FanciulliNeuroendocrine Tumour Unit, Department of Medicine, Surgery and Pharmacy, University of Sassari-Endocrine Unit, AOU Sassari, Sassari, Italy.
P MalandrinoEndocrinology Unit, Department of Clinical and Experimental Medicine, University of Catania and Garibaldi, Nesima Medical Center, Catania, Italy.
A M IsidoriDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
A ColaoEndocrinology, Diabetology and Andrology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy.
A FaggianoEndocrinology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, ENETS Center of Excellence, Rome, Italy.
NIKE Group
University of Naples Federico II · ITA. O. Ordine Mauriziano di Torino · ITOspedale San Luigi Gonzaga · ITAzienda Ospedaliera Sant'Andrea · ITHumanitas University · ITIRCCS Humanitas Research Hospital · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITOspedale Policlinico San Martino · ITSapienza University of Rome · ITUniversity of Ferrara · ITUniversity of Genoa · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITCTO Andrea Alesini · ITFederico II University Hospital · ITMagna Graecia University · ITUniversity of Catania · ITUniversity of Messina · ITUniversity of Palermo · ITUniversity of Sassari · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe incidence of neuroendocrine neoplasm (NEN) and related carcinoid syndrome (CaS) has increased markedly in recent decades, and women appear to be more at risk than men. As per other tumors, gender may be relevant in influencing the clinical and prognostic characteristics of NEN-associated CS. However, specific data on carcinoid syndrome (CaS) are still lacking. PURPOSE: To evaluate gender differences in clinical presentation and outcome of CaS.

methodsRetrospective analysis of 144 CaS patients from 20 Italian high-volume centers was conducted. Clinical presentation, tumor characteristics, therapies, and outcomes (progression-free survival, PFS, overall survival, OS) were correlated to gender.

resultsNinety (62.5%) CaS patients were male. There was no gender difference in the site of primary tumor, tumor grade and clinical stage, as well as in treatments. Men were more frequently smokers (37.2%) and alcohol drinkers (17.8%) than women (9.5%, p = 0.002, and 3.7%, p = 0.004, respectively). Concerning clinical presentation, women showed higher median number of symptoms (p = 0.0007), more frequent abdominal pain, tachycardia, and psychiatric disorders than men (53.3% vs 70.4%, p = 0.044; 6.7% vs 31.5%, p = 0.001; 50.9% vs. 26.7%, p = 0.003, respectively). Lymph node metastases at diagnosis were more frequent in men than in women (80% vs 64.8%; p = 0.04), but no differences in terms of PFS (p = 0.51) and OS (p = 0.64) were found between gender.

conclusionsIn this Italian cohort, CaS was slightly more frequent in males than females. Gender-related differences emerged in the clinical presentation of CaS, as well as gender-specific risk factors for CaS development. A gender-driven clinical management of these patients should be advisable.

Indexed as

Carcinoid TumorNeuroendocrine TumorsFemaleHumansItalyMalePrognosisRetrospective StudiesSex FactorsCarcinoid syndromeGenderGender medicineNeuroendocrine neoplasmNeuroendocrine tumorsPrognosisSex

Identifiers

PMID37837555
PMCPMC10965670
OpenAlexW4387641652

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