Evidence map›Paper›PMID 37837551›Full record

ArticleAging2023

Dysregulated expression of slingshot protein phosphatase 1 (SSH1) disrupts circadian rhythm and WNT signaling associated to hepatocellular carcinoma pathogenesis.

Shiue-Wei Lai, Yi-Chiao Cheng, Wen-Chien Huang, Vijesh Kumar Yadav, Iat-Hang Fong, Chi-Tai Yeh, Ching-Kuo Yang, Wei-Hwa Lee, Ming-Yao Chen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Shiue-Wei LaiDivision of Hematology/Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei City 114, Taiwan.
Yi-Chiao ChengDivision of Colon and Rectal Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei City 114, Taiwan.
Wen-Chien HuangDivision of Thoracic Surgery, Department of Surgery, MacKay Memorial Hospital, Taipei 104, Taiwan.
Vijesh Kumar YadavDivision of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 110, Taiwan.
Iat-Hang FongDivision of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 110, Taiwan.
Chi-Tai YehDivision of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 110, Taiwan.
Ching-Kuo YangDivision of Colorectal Surgery, Department of Surgery, Mackay Memorial Hospital, Taipei City 110, Taiwan.
Wei-Hwa LeeDepartment of Pathology, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan.
Ming-Yao ChenDivision of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 110, Taiwan.
National Defense Medical Center · TWTaipei Medical University · TWTaipei Medical University-Shuang Ho Hospital · TWMackay Medical College · TWMackay Memorial Hospital · TWNational Taitung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Growing evidence underscores the circadian rhythm's essential function in liver stability and disease. Its disruption is progressively linked with metabolic issues, oncogene triggers, and heightened cancer susceptibility. Research points to slingshot protein phosphatase 1 (SSH1), a modulator of cofilin-1 (CFL-1), as instrumental in the reformation of the actin cytoskeleton, thereby impacting the invasiveness of various cancer types. Yet, the dynamics of SSH1's influence on liver cell stemness and circadian activity remain unclear. Through

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsAnimalsARNTL Transcription Factorsbeta CateninCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMicePhosphoprotein PhosphatasesProtein Phosphatase 1Wnt Signaling PathwayARNTL Transcription Factorsbeta CateninPhosphoprotein PhosphatasesProtein Phosphatase 1SSH1 protein, humanSSH1 protein, mousecircadian rhythmhepatocellular carcinomasennoside A therapySSH1WNT/β-catenin signaling

Identifiers

PMID37837551
PMCPMC10637823
OpenAlexW4387613338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.