Evidence map›Paper›PMID 37837493›Full record

ArticleDermatology and therapy2023

Efficacy of Avène Hydrotherapy on Chronic Pruritus in Patients with Plaque Psoriasis.

Marie-Dominique Thouvenin, Adeline Bacquey, Marine Babin, Fabrice Lestienne, Christophe Lauze, Eléonore Gravier, Diana Placintescu, Ariadna Ortiz-Brugués, Sonja Ständer

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dermatology and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03023254 (An Exploratory Study to Assess the Efficacy of the Avène Hydrotherapy on Chronic Pruritus in Adults With Plaque Psoriasis), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03023254 nacompletednot on this map

An Exploratory Study to Assess the Efficacy of the Avène Hydrotherapy on Chronic Pruritus in Adults With Plaque Psoriasis

TypeinterventionalSponsorPierre Fabre Dermo CosmetiqueRan2017 to 2020Enrolled44ConditionsChronic Pruritus Due to Plaque PsoriasisArmsHydrotherapy
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Marie-Dominique ThouveninClinical Skin Research and Development Center, Pierre Fabre Dermo-Cosmétique, Toulouse, France. marie.dominique.thouvenin@pierre-fabre.com.ORCID http://orcid.org/0000-0003-1397-0076
Adeline BacqueyClinical Skin Research and Development Center, Pierre Fabre Dermo-Cosmétique, Toulouse, France.
Marine BabinClinical Skin Research and Development Center, Pierre Fabre Dermo-Cosmétique, Toulouse, France.
Fabrice LestiennePharmaco-Clinical Research Group, Pierre Fabre Dermo-Cosmétique, Toulouse, France.
Christophe LauzePharmaco-Clinical Research Group, Pierre Fabre Dermo-Cosmétique, Toulouse, France.
Eléonore GravierPharmaco-Clinical Research Group, Pierre Fabre Dermo-Cosmétique, Toulouse, France.
Diana PlacintescuStation Thermale Avène, Avène les Bains, France.
Ariadna Ortiz-BruguésMedical Direction, Laboratoires Dermatologiques Avène, Lavaur, France.
Sonja StänderCenter for Chronic Pruritus, Department of Dermatology, University Hospital Münster, Münster, Germany.
Pierre Fabre (France) · FRInstitut universitaire du cancer de Toulouse Oncopole · FRUniversity Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPruritus is a prevalent symptom, described as one of the most bothersome of psoriasis. Specific itch management remains a challenge, for which hydrotherapy could be used as adjunct care to medical treatment. Therefore, we assessed the immediate and longer-term benefit of 3 weeks of Avène thermal spring water hydrotherapy on chronic pruritus in patients in addition to their usual psoriasis and/or pruritus management.

methodsTwenty-six patients suffering from chronic pruritus due to psoriasis were evaluated before and after 3 weeks of hydrotherapy with a 3 and 6 month follow-up. A control group (18 patients) did not undergo hydrotherapy and continued to follow their usual skin management. Pruritus was assessed according to the numeric rating scale (NRS, pruritus intensity), the visual dynamic pruritus score (vDPS, change in pruritus intensity), and the 5-D itch scale (pruritus characteristics). Psoriasis severity was measured using the psoriasis area and severity index (PASI) score. The "itchy quality of life" (ItchQoL) scale was used to assess quality-of-life (QoL) impact related to itch. Pruritus and psoriasis gene and protein biomarkers were measured in lesional and nonlesional skin.

resultsPruritus measurements (NRS, vDPS, and 5-D itch scale) indicated an immediate and long-lasting positive effect of hydrotherapy compared with control patients. The psoriasis area and severity index (PASI) was decreased by 40.0% by hydrotherapy, which was sustained over 6 months. The ItchQoL also improved directly after hydrotherapy, which was still much improved even 6 months later. Analysis of gene and/or protein biomarkers revealed a significant decrease of inflammation biomarkers (IL-8, IL-1α, IL-1RA, and RANTES), of psoriasis biomarkers (PI3, S100A7, and IL-17), and of pruritus biomarkers (IL-31, TRPV1, and CGRP1).

conclusionsThese findings demonstrated an immediate and long-lasting improvement of pruritus in patients with psoriasis who underwent Avène thermal spring water hydrotherapy, indicating that this would be a good complementary therapy in the management of this disease.

trial registrationNCT03023254.

Indexed as

Avène hydrotherapyChronic pruritusClinicalItchPsoriasis

Identifiers

PMID37837493
PMCPMC10689587
OpenAlexW4387642362

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.