Evidence map›Paper›PMID 37837480›Full record

ArticleNeuroradiology2023

"Soap bubble" sign as an imaging marker for posterior fossa ependymoma Group B.

Ying Jin, Dan Cheng, Yunyun Duan, Zhizheng Zhuo, Jinyuan Weng, Chengzhou Zhang, Mingwang Zhu, Xing Liu, Jiang Du, Tiantian Hua and 4 more

Abstract read
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In one paragraph

Article in Neuroradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ying Jin *Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Dan Cheng *Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Yunyun DuanDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Zhizheng ZhuoDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Jinyuan WengDepartment of Medical Imaging Product, Neusoft, Group Ltd., Shenyang, 110179, China.
Chengzhou ZhangDepartment of Radiology, Yantai Yuhuangding Hospital, Yantai, 264000, Shandong, China.
Mingwang ZhuDepartment of Radiology, Sanbo Brain Hospital, Capital Medical University, Beijing, 100070, China.
Xing LiuDepartment of Pathology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Jiang DuDepartment of Pathology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Tiantian HuaDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Hongfang LiDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Sven HallerDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Frederik BarkhofDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
Yaou LiuDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. yaouliu80@163.com.ORCID http://orcid.org/0000-0002-9930-0331

Funding

Beijing Municipal Natural Science Foundation for Distinguished Young Scholars JQ20035National Science Foundation of China 81571631National Science Foundation of China 81870958Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Hospitals Authority XTYB201831
6 · The paper itself

Abstract

purposeTo investigate the predictive value of the "soap bubble" sign on molecular subtypes (Group A [PFA] and Group B [PFB]) of posterior fossa ependymomas (PF-EPNs).

methodsMRI scans of 227 PF-EPNs (internal retrospective discovery set) were evaluated by two independent neuroradiologists to assess the "soap bubble" sign, which was defined as clusters of cysts of various sizes that look like "soap bubbles" on T2-weighted images. Two independent cohorts (external validation set [n = 31] and prospective validation set [n = 27]) were collected to validate the "soap bubble" sign.

resultsAcross three datasets, the "soap bubble" sign was observed in 21 PFB cases (7.4% [21/285] of PF-EPNs and 12.9% [21/163] of PFB); none in PFA. Analysis of the internal retrospective discovery set demonstrated substantial interrater agreement (1st Rating: κ = 0.71 [0.53-0.90], 2nd Rating: κ = 0.83 [0.68-0.98]) and intrarater agreement (Rater 1: κ = 0.73 [0.55-0.91], Rater 2: κ = 0.74 [0.55-0.92]) for the "soap bubble" sign; all 13 cases positive for the "soap bubble" sign were PFB (p = 0.002; positive predictive value [PPV] = 100%, negative predictive value [NPV] = 44%, sensitivity = 10%, specificity = 100%). The findings from the external validation set and the prospective validation set were similar, all cases positive for the "soap bubble" sign were PFB (p < 0.001; PPV = 100%).

conclusionThe "soap bubble" sign represents a highly specific imaging marker for the PFB molecular subtype of PF-EPNs.

Indexed as

EpendymomaHumansMagnetic Resonance ImagingRetrospective StudiesSoapsSoapsMagnetic resonance imagingMolecular subtypePosterior fossa ependymomaSoap bubble

Identifiers

PMID37837480

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.