Evidence map›Paper›PMID 37837329›Full record

ArticleThoracic cancer2023

First case report of erlotinib plus ramucirumab treatment for lung carcinosarcoma with EGFR L858R mutation.

Naoya Ishibashi, Toshiharu Tabata, Ryo Nonomura, Yutaka Oshima, Takanobu Sasaki, Hideki Mitomo, Takafumi Sugawara, Motoyasu Sagawa

Open access · goldAbstract readCase Reports
In one paragraph

Article in Thoracic cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Naoya IshibashiDepartment of Thoracic Surgery, Tohoku Medical and Pharmaceutical University Hospital, Sendai City, Japan.ORCID 0009-0005-8587-0439
Toshiharu TabataDepartment of Thoracic Surgery, Tohoku Medical and Pharmaceutical University Hospital, Sendai City, Japan.
Ryo NonomuraDepartment of Thoracic Surgery, Tohoku Medical and Pharmaceutical University Hospital, Sendai City, Japan.
Yutaka OshimaDepartment of Thoracic Surgery, Tohoku Medical and Pharmaceutical University Hospital, Sendai City, Japan.
Takanobu SasakiDepartment of Thoracic Surgery, Tohoku Medical and Pharmaceutical University Hospital, Sendai City, Japan.
Hideki MitomoDepartment of Thoracic Surgery, Tohoku Medical and Pharmaceutical University Hospital, Sendai City, Japan.
Takafumi SugawaraDepartment of Thoracic Surgery, Tohoku Medical and Pharmaceutical University Hospital, Sendai City, Japan.
Motoyasu SagawaDepartment of Thoracic Surgery, Tohoku Medical and Pharmaceutical University Hospital, Sendai City, Japan.
Tohoku Medical and Pharmaceutical University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung carcinosarcoma is acknowledged as a rare form of lung cancer. Due to its rarity, the inability to conduct large-scale clinical trials and interventions is currently carried out based on empirical evidence. In this study, we report the case of a 73-year-old female patient diagnosed with postoperative recurrence of lung carcinosarcoma. The resected tumor was diagnosed as lung carcinosarcoma, and genetic testing revealed the presence of the epidermal growth factor receptor (EGFR) exon21 L858R. Approximately 2 years postoperatively, the tumor recurred and the patient was treated with erlotinib plus ramucirumab, which were effective in controlling metastatic disease. Erlotinib plus ramucirumab is therefore a treatment option for EGFR mutation-positive lung carcinosarcoma.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsAgedErbB ReceptorsErlotinib HydrochlorideFemaleHumansLungMutationProtein Kinase InhibitorsRamucirumabEGFR protein, humanErbB ReceptorsErlotinib HydrochlorideProtein Kinase InhibitorsRamucirumabEGFR L858Rerlotiniblung carcinosarcomanon-small cell lung cancerramucirumab

Identifiers

PMID37837329
PMCPMC10693942
OpenAlexW4387640085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.