Evidence map›Paper›PMID 37836771›Full record

ArticleMolecules (Basel, Switzerland)2023

Synthesis and Characterization of Edaravone Analogues as Remyelinating Agents and Putative Mechanistic Probes.

Eleonora Colombo, Stefania Olla, Cristina Minnelli, Alessia Formato, Caterina Veroni, Silvia Corbisiero, Mattia Pericolo, Chiara Siguri, Giovanna Mobbili, Cristina Agresti and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Eleonora ColomboChemistry Department, University of Milan, Via Golgi 19, 20133 Milan, Italy.ORCID 0000-0001-9062-4850
Stefania OllaBiomedical and Genetic Research Institute (IRGB, National Research Council (CNR)), University Campus, Monserrato, 09042 Monserrato, Italy.ORCID 0000-0001-8735-671X
Cristina MinnelliDepartment of Life and Environmental Sciences, Marche Polytechnic University, Via Brecce Bianche, 60131 Ancona, Italy.ORCID 0000-0001-8034-8557
Alessia FormatoDepartment of Neuroscience, National Institute of Health (ISS), Viale Regina Elena 299, 00161 Rome, Italy.
Caterina VeroniDepartment of Neuroscience, National Institute of Health (ISS), Viale Regina Elena 299, 00161 Rome, Italy.
Silvia CorbisieroDepartment of Neuroscience, National Institute of Health (ISS), Viale Regina Elena 299, 00161 Rome, Italy.ORCID 0000-0001-7360-6570
Mattia PericoloChemistry Department, University of Milan, Via Golgi 19, 20133 Milan, Italy.
Chiara SiguriBiomedical and Genetic Research Institute (IRGB, National Research Council (CNR)), University Campus, Monserrato, 09042 Monserrato, Italy.
Giovanna MobbiliDepartment of Life and Environmental Sciences, Marche Polytechnic University, Via Brecce Bianche, 60131 Ancona, Italy.ORCID 0000-0003-0243-5844
Cristina AgrestiDepartment of Neuroscience, National Institute of Health (ISS), Viale Regina Elena 299, 00161 Rome, Italy.ORCID 0000-0002-9225-7190
Pierfausto SeneciChemistry Department, University of Milan, Via Golgi 19, 20133 Milan, Italy.ORCID 0000-0001-9709-7344
Istituto Superiore di Sanità · ITUniversity of Milan · ITInstitute of Genetic and Biomedical Research · ITMarche Polytechnic University · IT

Funding

Fondazione Italiana Sclerosi Multipla 2017/R/2
6 · The paper itself

Abstract

Edaravone (EDA), an antioxidant drug approved for the treatment of ischemic stroke and amyotrophic lateral sclerosis, was recently proposed as a remyelinating candidate for the treatment of multiple sclerosis. Here, we synthesized twelve EDA analogues

Indexed as

Amyotrophic Lateral SclerosisAntioxidantsEdaravoneEstersHumansOxidative StressAntioxidantsEdaravoneEstersabsorption-distribution-metabolism-excretion (ADME)amyotrophic lateral sclerosisantioxidant activitychemical probesedaravonemechanism of actionmedicinal chemistryprodrugsremyelination

Identifiers

PMID37836771
PMCPMC10574562
OpenAlexW4387343668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.