Evidence map›Paper›PMID 37836759›Full record

ArticleMolecules (Basel, Switzerland)2023

Further Quinolizidine Derivatives as Antiarrhythmic Agents- 3.

Bruno Tasso, Laura Beatrice Mattioli, Michele Tonelli, Vito Boido, Alberto Chiarini, Fabio Sparatore, Roberta Budriesi

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Antiviral Activity of (1Molecules (Basel, Switzerland) · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Bruno TassoDepartment of Pharmacy, University of Genova, 16132 Genova, Italy.ORCID 0000-0002-5636-5645
Laura Beatrice MattioliFood Chemistry and Nutraceutical Research Unit, Department of Pharmacy & Biotechnology, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.
Michele TonelliDepartment of Pharmacy, University of Genova, 16132 Genova, Italy.ORCID 0000-0003-1518-2890
Vito BoidoDepartment of Pharmacy, University of Genova, 16132 Genova, Italy.
Alberto ChiariniFood Chemistry and Nutraceutical Research Unit, Department of Pharmacy & Biotechnology, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.
Fabio SparatoreDepartment of Pharmacy, University of Genova, 16132 Genova, Italy.ORCID 0000-0002-1657-9024
Roberta BudriesiFood Chemistry and Nutraceutical Research Unit, Department of Pharmacy & Biotechnology, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-8454-9740
University of Genoa · ITUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fourteen quinolizidine derivatives, structurally related to the alkaloids lupinine and cytisine and previously studied for other pharmacological purposes, were presently tested for antiarrhythmic, and other cardiovascular effects on isolated guinea pig heart tissues in comparison to well-established reference drugs. According to their structures, the tested compounds are assembled into three subsets: (a) N-(quinolizidinyl-alkyl)-benzamides; (b) 2-(benzotriazol-2-yl)methyl-1-(quinolizidinyl)alkyl-benzimidazoles; (c) N-substituted cytisines. All compounds but two displayed antiarrhythmic activity that was potent for compounds

Indexed as

AlkaloidsQuinolizidinesSparteineAnimalsAnti-Arrhythmia AgentsArrhythmias, CardiacGuinea PigsHeartRatsAlkaloidsAnti-Arrhythmia AgentsQuinolizidinesSparteineantiarrhythmic activitycytisineinotropic and chronotropic activitieslupininequinolizidine derivativessparteinevasorelaxant activity

Identifiers

PMID37836759
PMCPMC10574513
OpenAlexW4387306401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.