ArticleMolecules (Basel, Switzerland)2023
Antioxidant Peptides from the Collagen of Antler Ossified Tissue and Their Protective Effects against H
Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Novel antioxidant peptides from chicken bone hydrolysate: Identification, structure-activity relationship and cytoprotective effects against oxidative stress in HaCaT cells.Food chemistry: X · 2026Article
- Deer antler velvet as a multifunctional natural resource for biomedical and nutraceutical applications.Food science of animal resources · 2026Review
- Identification and Functional Characterization of Cytoprotective Crocodile-Derived Peptides against Oxidatively Stressed Human Keratinocytes.ACS omega · 2026Article
- Modern Advances in Velvet Antler Research: From Identification Methods to Pharmacological Mechanisms.International journal of food science · 2026Review
- Extraction, Purification and Identification of Bovine Lung Peptides and Its Antioxidant Effects on HAntioxidants (Basel, Switzerland) · 2025Article
- Identification and Characterization of Glycine- and Proline-Rich Antioxidant Peptides From Antler Residues Based on Peptidomics, Machine Learning, and Molecular Docking.Food science & nutrition · 2025Article
- Preparation, characterization and antioxidative activity analysis of recombinant humanized collagen type III-loaded liposomes.Scientific reports · 2025Article
- Preparation and tissue structure analysis of horse bone collagen peptide.Scientific reports · 2024Article
- Skin Improvement Effects of Ultrasound-Enzyme-Treated Collagen Peptide Extracts from Flatfish (International journal of molecular sciences · 2024Article
- Valorizing sardine scales: a circular approach to sustainable collagen for cosmetics and nutrition applications.Frontiers in pharmacology · 2024Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Antler ossified tissue has been widely used for the extraction of bioactive peptides. In this study, collagen was prepared from antler ossified tissue via acetic acid and pepsin. Five different proteases were used to hydrolyze the collagen and the hydrolysate treated by neutrase (collagen peptide named ACP) showed the highest DPPH radical clearance rate. The extraction process of ACP was optimized by response surface methodology, and the optimal conditions were as follows: a temperature of 52 °C, a pH of 6.1, and an enzyme concentration of 3200 U/g, which resulted in the maximum DPPH clearance rate of 74.41 ± 0.48%. The peptides (ACP-3) with the strongest antioxidant activity were obtained after isolation and purification, and its DPPH free radical clearance rate was 90.58 ± 1.27%; at the same time, it exhibited good scavenging activity for ABTS, hydroxyl radical, and superoxide anion radical. The study investigated the protective effect of ACP-3 on oxidative damage in HaCaT cells. The findings revealed that all groups that received ACP-3 pretreatment exhibited increased activities of SOD, GSH-Px, and CAT compared to the model group. Furthermore, ACP-3 pretreatment reduced the levels of ROS and MDA in HaCaT cells subjected to H
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