Evidence map›Paper›PMID 37836687›Full record

ArticleMolecules (Basel, Switzerland)2023

A Novel Method for γ-Aminobutyric Acid Biosynthesis Using Glutamate Decarboxylase Entrapped in Polyvinyl Alcohol-Sodium Alginate Capsules.

Fei Zhu, Sheng Hu, Weirui Zhao, Lehe Mei

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Fei ZhuDepartment of Food Science, Zhejiang Pharmaceutical University, Ningbo 315000, China.
Sheng HuSchool of Biological and Chemical Engineering, NingboTech University, Ningbo 315000, China.
Weirui ZhaoSchool of Biological and Chemical Engineering, NingboTech University, Ningbo 315000, China.
Lehe MeiCollege of Chemical and Biochemical Engineering, Zhejiang University, Hangzhou 310058, China.
Ningbo University of Technology · CNJinhua Academy of Agricultural Sciences · CNZhejiang Pharmaceutical College · CN

Funding

2022 Zhejiang Provincial Higher Education Institution Domestic Visiting Engineer University-enterprise Cooperation Project; National Natural Science Foundation of China; Ningbo Scientific and Technological innovation 2025 key project FG2022007; 31971372; 2020Z080
6 · The paper itself

Abstract

γ-aminobutyric acid (GABA) has essential physiological functions in the human body. A novel method using glutamate decarboxylase (GAD) entrapped in polyvinyl alcohol (PVA)-sodium alginate (SA) capsules provides a green biological strategy for GABA synthesis. In this investigation, the stability range of immobilized GAD was effectively broadened, and immobilized GAD could be repeatedly used as a batch and fixed-bed column catalyst. The immobilized enzymes were stable and retained 89% of their activity in a pH range of 4.0-5.6, while there was an approximately 50% decrease in free GAD activity in the pH range of 4.8 ± 0.4. The immobilized GAD affinity to the substrate improved, and this was evidenced by the apparent decrease in

Indexed as

Glutamate DecarboxylasePolyvinyl AlcoholAlginatesEnzymes, Immobilizedgamma-Aminobutyric AcidGlutamic AcidHumansAlginatesEnzymes, Immobilizedgamma-Aminobutyric AcidGlutamate DecarboxylaseGlutamic AcidPolyvinyl Alcoholbiosynthesiscapsulesglutamate decarboxylaseimmobilizationpolyvinyl alcoholsodium alginateγ-aminobutyric acid

Identifiers

PMID37836687
PMCPMC10574615
OpenAlexW4387138230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.