Evidence map›Paper›PMID 37836604›Full record

ArticleMolecules (Basel, Switzerland)2023

Substrate-Controlled Diversity-Oriented Synthesis of Novel Polycyclic Frameworks via [4 + 2] and [3 + 2] Annulations of Ninhydrin-Derived MBH Adducts with 3,4-Dihydroisoquinolines.

Kaikai Wang, Wenwen Zhou, Jun Jia, Junwei Ye, Mengxin Yuan, Jie Yang, Yonghua Qi, Rongxiang Chen

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kaikai WangSchool of Pharmacy, Xinxiang University, Xinxiang 453000, China.ORCID 0000-0002-6107-1019
Wenwen ZhouSchool of Pharmacy, Xinxiang University, Xinxiang 453000, China.
Jun JiaJilin Province Product Quality Supervision and Inspection Institute, Changchun 130012, China.
Junwei YeSchool of Pharmacy, Xinxiang University, Xinxiang 453000, China.
Mengxin YuanSchool of Pharmacy, Xinxiang University, Xinxiang 453000, China.
Jie YangSchool of Chemistry & Materials Engineering, Xinxiang University, Xinxiang 453000, China.
Yonghua QiSchool of Pharmacy, Xinxiang University, Xinxiang 453000, China.
Rongxiang ChenSchool of Pharmacy, Xinxiang University, Xinxiang 453000, China.ORCID 0000-0002-3843-2074

Funding

Henan Province professional degree graduate excellent teaching case project YJS2023AL094National Natural Science Foundation of China 21801214Science and Technology Research Program of Henan Province 202102210232the Higher Education Institution Key Research Project Plan of Henan Province 23A150044the Program for Youth Backbone Teacher Training in University of Henan Province 2021GGJS163
6 · The paper itself

Abstract

Substrate-controlled diversity-oriented synthesis of polycyclic frameworks via [4 + 2] and [3 + 2] annulations between ninhydrin-derived Morita-Baylis-Hillman (MBH) adducts and 3,4-dihydroisoquinolines under similar reaction conditions have been developed. The reaction provides diversity-oriented synthesis of a series of novel and structurally complex spiro multi heterocyclic skeletons in good yields (up to 87% and 90%, respectively) with excellent diastereoselectivities (up to >25:1

Indexed as

[3 + 2] cycloaddition3,4-dihydroisoquinolinescycloadditionDiels-Alder reactionninhydrin-derived MBH adductspolycyclic frameworkssubstrate-controlled

Identifiers

PMID37836604
PMCPMC10574269

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.