Evidence map›Paper›PMID 37836603›Full record

ArticleMolecules (Basel, Switzerland)2023

Compatibility of Nucleobases Containing Pt(II) Complexes with Red Blood Cells for Possible Drug Delivery Applications.

Federica De Castro, Erika Stefàno, Francesco Paolo Fanizzi, Riccardo Di Corato, Pasant Abdalla, Francesca Luchetti, Maria Gemma Nasoni, Rosaria Rinaldi, Mauro Magnani, Michele Benedetti and 1 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Federica De CastroDepartment of Biological and Environmental Sciences and Technologies, University of Salento, Via Monteroni, 73100 Lecce, Italy.ORCID 0000-0001-5060-293X
Erika StefànoDepartment of Biological and Environmental Sciences and Technologies, University of Salento, Via Monteroni, 73100 Lecce, Italy.
Francesco Paolo FanizziDepartment of Biological and Environmental Sciences and Technologies, University of Salento, Via Monteroni, 73100 Lecce, Italy.ORCID 0000-0003-3073-5772
Riccardo Di CoratoCenter for Biomolecular Nanotechnologies, Istituto Italiano di Tecnologia, 73010 Arnesano, Italy.ORCID 0000-0002-7173-6176
Pasant AbdallaDipartimento di Scienze Biomolecolari, Università degli Studi di Urbino Carlo Bo, Via Saffi 2, 61029 Urbino, Italy.ORCID 0000-0003-1975-5713
Francesca LuchettiDipartimento di Scienze Biomolecolari, Università degli Studi di Urbino Carlo Bo, Via Saffi 2, 61029 Urbino, Italy.
Maria Gemma NasoniDipartimento di Scienze Biomolecolari, Università degli Studi di Urbino Carlo Bo, Via Saffi 2, 61029 Urbino, Italy.ORCID 0000-0002-2078-7774
Rosaria RinaldiInstitute for Microelectronics and Microsystems (IMM), CNR, Via Monteroni, 73100 Lecce, Italy.ORCID 0000-0003-2798-9341
Mauro MagnaniDipartimento di Scienze Biomolecolari, Università degli Studi di Urbino Carlo Bo, Via Saffi 2, 61029 Urbino, Italy.ORCID 0000-0001-6456-6626
Michele BenedettiDepartment of Biological and Environmental Sciences and Technologies, University of Salento, Via Monteroni, 73100 Lecce, Italy.ORCID 0000-0001-9936-9649
Antonella AntonelliDipartimento di Scienze Biomolecolari, Università degli Studi di Urbino Carlo Bo, Via Saffi 2, 61029 Urbino, Italy.ORCID 0000-0002-5931-4616

Funding

Italian MInistry of University (MIUR) PON "BIO-D" project "Sviluppo di Biomarcatori Diagnostici per la medicina di precisione e la terapia personalizzata" ARS01_00876
6 · The paper itself

Abstract

The therapeutic advantages of some platinum complexes as major anticancer chemotherapeutic agents and of nucleoside analogue-based compounds as essential antiviral/antitumor drugs are widely recognized. Red blood cells (RBCs) offer a potential new strategy for the targeted release of therapeutic agents due to their biocompatibility, which can protect loaded drugs from inactivation in the blood, thus improving biodistribution. In this study, we evaluated the feasibility of loading model nucleobase-containing Pt(II) complexes into human RBCs that were highly stabilized by four

Indexed as

Antineoplastic AgentsOrganoplatinum CompoundsAntiviral AgentsErythrocytesGuanosineHumansPlatinumTissue DistributionAntineoplastic AgentsAntiviral AgentsGuanosineOrganoplatinum CompoundsPlatinumcisplatincoordination compoundsdrug delivery systemsnucleoside analoguesplatinum drugsred blood cells

Identifiers

PMID37836603
PMCPMC10574024

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.