ReviewNutrients2023
Anti-Inflammatory and Anti-Allergic Properties of Colostrum from Mothers of Full-Term and Preterm Babies: The Importance of Maternal Lactation in the First Days.
Review in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- The Effects of Colostrum Bovinum Supplementation on Human Body Fat Content and/or Blood Lipid Profile: A Systematic Review of Clinical Trials.Nutrients · 2026Pooled it
- Incidence and factors influencing delayed onset of lactation: a systematic review and meta-analysis.International breastfeeding journal · 2024Pooled it
- Combatting a Tobramycin-resistant Staphylococcus aureus outbreak in a neonatal intensive care unit: the impact of hygiene intervention and antibiotic substitution.BMC infectious diseases · 2026Article
- Oral care with human milk is associated with increased human milk feeding and breastfeeding for newborns with critical congenital heart disease.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Prenatal diazepam exposure impairs maternal caregiving behaviors in rats: Roles of GABAARα1 downregulation, serotonin depletion, and corticosterone dysregulation.Toxicology reports · 2026Article
- Comparative Analysis of Adipokines and Growth Factors in Preterm and Term Breast Milk and Their Role in Infant Growth.Current nutrition reports · 2026Review
- Early Deficient Lactation Differentially Affects Neonatal Thymic Cortical Development and Humoral Immune Responses in Rats.International journal of molecular sciences · 2026Article
- Progress of Section "Bioorganic Chemistry and Medicinal Chemistry".Current issues in molecular biology · 2025Article
- Little women: the relevance and reliance on mouse models for mammary gland research and next steps for translation.Journal of mammary gland biology and neoplasia · 2025Review
- Factors Influencing the Colostrum's Microbiota: A Systematic Review of the Literature.Children (Basel, Switzerland) · 2025Review
- Association of monocyte to lymphocyte ratio with length of stay in intensive care unit in neonatal apnea modified by treatment.Translational pediatrics · 2025Article
- They will be famous: Multipotent stem cells in breast milk.World journal of clinical pediatrics · 2025Review
- From Mother-Fetus Dyad to Mother-Milk-Infant Triad: Sex Differences in Macronutrient Composition of Breast Milk.Nutrients · 2025Article
- The Legacy of COVID-19 in Breast Milk: The Association of Elevated Anti-Inflammatory and Antimicrobial Proteins with Vaccination or Infection.Current issues in molecular biology · 2025Article
- The influence of human milk composition and its microbiome on the gut microecology and early growth and development of preterm infants (the YI study): protocol design and cohort profile.Frontiers in nutrition · 2025Article
- Science and Faith to Understand Milk Bioactivity for Infants.Nutrients · 2024Review
- New policies on skin-to-skin contact warrant an oxytocin-based perspective on perinatal health care.Frontiers in psychology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our narrative review focuses on colostrum components, particularly those that influence the neonatal immune system of newborns. Colostrum is secreted in small volumes by the alveolar cells of the breast during the first two to five days after birth. Colostrum is poor in fat and carbohydrates, with larger protein and bioactive compounds than mature milk. It plays a crucial role in driving neonates' immunity, transferring those immunological factors which help the correct development of the neonatal immune system and support establishing a healthy gut microbiome. The newborn has an innate and adaptive immune system deficiency, with a consequent increase in infection susceptibility. In particular, neonates born prematurely have reduced immunological competencies due to an earlier break in the maternal trans-placenta transfer of bioactive components, such as maternal IgG antibodies. Moreover, during pregnancy, starting from the second trimester, maternal immune cells are conveyed to the fetus and persist in small quantities post-natal, whereby this transfer is known as microchimerism (MMc). Thus, preterm newborns are deficient in this maternal heritage, and have their own immune system under-developed, but colostrum can compensate for the lack. Early breastfeeding, which should be strongly encouraged in mothers of preterm and full-term babies, provides those immunomodulant compounds that can act as a support, allowing the newborn to face immune needs, including fronting infections and establishing tolerance. Moreover, making mothers aware that administering colostrum helps their infants in building a healthy immune system is beneficial to sustain them in the difficult post-partum period.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.