Evidence map›Paper›PMID 37836532›Full record

Trial reportNutrients2023

Effects of Synbiotic Supplementation on Metabolic Syndrome Traits and Gut Microbial Profile among Overweight and Obese Hong Kong Chinese Individuals: A Randomized Trial.

Susana Lauw, Nelson Kei, Po Lam Chan, Tsz Kwan Yau, Ka Lee Ma, Carol Ying Ying Szeto, Janice Su-Chuen Lin, Sunny Hei Wong, Peter Chi Keung Cheung, Hoi Shan Kwan

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07720232 (Effect of Bacillus Subtilis and Enterococcus Faecium Combination Therapy Combined With Conventional Lipid-Lowering Treatment on Triglyceride Levels in Patients With Hypertriglyceridemic Acute Pancreatitis), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07720232 phase4recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of Bacillus Subtilis and Enterococcus Faecium Combination Therapy Combined With Conventional Lipid-Lowering Treatment on Triglyceride Levels in Patients With Hypertriglyceridemic Acute Pancreatitis: A Prospective Randomized Controlled Trial

TypeinterventionalSponsorJianyin ZhouRan2026 to 2029Enrolled180ConditionsHypertriglyceridemic Acute Pancreatitis, Acute Pancreatitis, Hypertriglyceridemia-induced, HyperlipidemiaArmsLive Combined Bacillus subtilis and Enterococcus faecium Enteric-coated Capsules (LCBE), Standard Care (in control arm)
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Effects ofFrontiers in microbiology · 2025
    Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Recent Studies on the Effectiveness and Safety of Anti-Obesity Medications: A Scoping Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Effect ofFrontiers in nutrition · 2025
    Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Susana LauwFood and Nutritional Sciences Program, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0009-0008-7751-6159
Nelson KeiFood and Nutritional Sciences Program, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0009-0005-8247-6196
Po Lam ChanFood Research Centre, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-1329-9721
Tsz Kwan YauCell and Molecular Biology Program, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0009-0002-1325-6227
Ka Lee MaFood and Nutritional Sciences Program, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-4533-5547
Carol Ying Ying SzetoHSK GeneTech Limited, Hong Kong SAR, China.
Janice Su-Chuen LinDepartment of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Sunny Hei WongLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.ORCID 0000-0002-3354-9310
Peter Chi Keung CheungFood and Nutritional Sciences Program, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0001-5155-7173
Hoi Shan KwanFood Research Centre, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-7943-2513
Chinese University of Hong Kong · HKNanyang Technological University · SG

Funding

Food Research Centre of The Chinese University of Hong KongResearch Grants Council of Hong Kong SAR R5034-18
6 · The paper itself

Abstract

In view of the limited evidence showing anti-obesity effects of synbiotics via modulation of the gut microbiota in humans, a randomized clinical trial was performed. Assessment of the metabolic syndrome traits and profiling of the fecal gut microbiota using 16S rRNA gene sequencing in overweight and obese Hong Kong Chinese individuals before and after dietary intervention with an 8-week increased consumption of fruits and vegetables and/or synbiotic supplementation was conducted. The selected synbiotic contained two probiotics (

Indexed as

Gastrointestinal MicrobiomeMetabolic SyndromeProbioticsSynbioticsDietary FiberDouble-Blind MethodEast Asian PeopleHong KongHumansObesityOverweightRNA, Ribosomal, 16SDietary FiberRNA, Ribosomal, 16Sdietfruits and vegetablesgut healthgut microbiotainsulin resistancemetabolic syndromeobesityprobioticssynbioticsweight loss

Identifiers

PMID37836532
PMCPMC10574554
OpenAlexW4387264787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.