ArticleNutrients2023
Evaluation of Serum Diamine Oxidase as a Diagnostic Test for Histamine Intolerance.
Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Measurement of diamine oxidase (DAO) during low-histamine or ordinary diet in patients with histamine intolerance.European journal of clinical nutrition · 2024Trial
- Article
- Diamine Oxidase and Gastrointestinal Diseases.Biomolecules · 2026Review
- Markedly Increased Diamine Oxidase During Acute Anaphylaxis Is Associated With an Underlying Clonal Mast Cell Disorder.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Article
- Serum Immunometabolic Biomarkers Reveal Distinct Phenotypes in Chronic Urticaria.Diagnostics (Basel, Switzerland) · 2026Article
- The Prevalence of Diamine Oxidase Polymorphisms and Their Association with Histamine Intolerance Symptomatology in the Mexican Population.Biomedicines · 2025Article
- Improvement of Histamine Intolerance Symptoms in Pregnant Women with Diamine Oxidase Deficiency: An Exploratory Study.Journal of clinical medicine · 2025Article
- Estimation of serum levels of mast cells-related chymase, histamine and diamine oxidase in oral submucous fibrosis- a preliminary report.BMC oral health · 2025Article
- Spectrum, Time Course, Stages, and a Proposal for the Diagnosis of Histamine Intolerance in General Practice: A Nonrandomized, Quasi-Experimental Study.Journal of clinical medicine · 2025Article
- Therapeutic efficacy of fecal microbiota transplantation in severe food intolerance: a case report.Frontiers in nutrition · 2025Article
- Article
- Histamine Intolerance: Symptoms, Diagnosis, and Beyond.Nutrients · 2024Review
- Pilot Study on the Prevalence of Diamine Oxidase Gene Variants in Patients with Symptoms of Histamine Intolerance.Nutrients · 2024Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Histamine intolerance (HIT) is a clinical condition caused by decreased intestinal degradation of ingested histamine, primarily due to reduced enzyme diamine oxidase (DAO) activity, leading to histamine accumulation and causing various clinical manifestations. The measurement of serum DAO is commonly used as the main diagnostic test for HIT, although its diagnostic use is still uncertain. In this retrospective study, we aimed to assess the validity of DAO determination in patients with clinically suspected HIT. We measured DAO levels in 249 patients with suspected HIT and 50 healthy adult controls without HIT-related problems. Based on five clinical criteria, we divided patients into two groups: high (all five inclusion criteria; 41 patients) and low probability of HIT (≤4 inclusion criteria; 208 patients). Patients with a "high probability of HIT" had the lowest DAO (median: 8 U/mL, IQR: 6-10) in comparison to patients with a "low probability of HIT (median: 10 U/mL, IQR: 7-16,
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